SERPINE1 and SGTA

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SERPINE1	SGTA
Gene Name		serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding	Protein Binding
	Biological Process	Chronological Cell Aging Angiogenesis Platelet Degranulation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Circadian Rhythm Gene Expression Regulation Of Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Cell Proliferation Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process	Biological_process Viral Process
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation Dissolution of Fibrin Clot TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Response to elevated platelet cytosolic Ca2+ ECM proteoglycans TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD4 MH2 Domain Mutants in Cancer
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone
Diseases
GWAS		Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		19 interactors: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN	92 interactors: ADIPOQ AGR3 BAG6 BCL2L12 C1QA C1QTNF1 C1QTNF6 C3orf52 CARKD CCDC155 CD79B CD99 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NME3 NXF1 PBXIP1 PCDHA4 PFN2 PIAS1 PPIB PPIC PPP1R3C PRAP1 PTN RARRES3 RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B
Entrez ID		5054	6449
HPRD ID		01418	04568
Ensembl ID		ENSG00000106366	ENSG00000104969
Uniprot IDs		P05121	O43765
PDB IDs		1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 9PAI	2VYI 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Fibrinolysis Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Migration Regulation Of Wound Healing Extracellular Matrix Disassembly Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Abiotic Stimulus Blood Coagulation Hemostasis Acute Inflammatory Response Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress Response To Hypoxia Regulation Of Cell Migration Wound Healing Proteolysis Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Motility Endocytosis Receptor-mediated Endocytosis Response To Wounding Regulation Of Signaling Smooth Muscle Cell Migration Response To Stimulus Positive Regulation Of Blood Coagulation Cell Migration Regulation Of Cellular Protein Metabolic Process Platelet Activation Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Muscle Cell Migration Acute-phase Response Cell Motility Positive Regulation Of Coagulation Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Cellular Component Movement Regulation Of Cellular Response To Oxidative Stress Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion	Response To Stress Protein Heterotrimerization Extracellular Matrix Organization Extracellular Structure Organization Defense Response Regulation Of Immune System Process Protein Trimerization Macrophage Apoptotic Process Response To Wounding Regulation Of Secretion Immune System Process Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Cell Proliferation Protein Heterooligomerization Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Immune System Process Wound Healing Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Response To Heat Negative Regulation Of Proteolysis Positive Regulation Of Protein Modification Process Negative Regulation Of Protein Processing Developmental Process Multicellular Organismal Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Innate Immune Response Cellular Response To Stimulus Regulation Of Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Myeloid Cell Apoptotic Process Response To Organic Substance Protein Folding Regulation Of Protein Processing Response To Lipid Regulation Of Developmental Growth Protein Insertion Into ER Membrane Inflammatory Cell Apoptotic Process Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Immune Response Inflammatory Response Signal Transduction Positive Regulation Of Protein Metabolic Process
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	bag6 biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	bag6 biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Intersection) ?