SERPINE1 and LRP2

Number of citations of the paper that reports this interaction (PMID 8344937)
29

Data Source:
HPRD (in vitro)

		SERPINE1	LRP2
Gene Name		serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	low density lipoprotein receptor-related protein 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Chronological Cell Aging Angiogenesis Platelet Degranulation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Circadian Rhythm Gene Expression Regulation Of Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Cell Proliferation Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation Dissolution of Fibrin Clot TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Response to elevated platelet cytosolic Ca2+ ECM proteoglycans TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD4 MH2 Domain Mutants in Cancer	Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone	Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS		Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)	Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		19 interactors: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		5054	4036
HPRD ID		01418	02509
Ensembl ID		ENSG00000106366	ENSG00000081479
Uniprot IDs		P05121	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 9PAI	2M0P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Fibrinolysis Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Migration Regulation Of Wound Healing Extracellular Matrix Disassembly Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Abiotic Stimulus Blood Coagulation Hemostasis Acute Inflammatory Response Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress Response To Hypoxia Regulation Of Cell Migration Wound Healing Proteolysis Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Motility Endocytosis Receptor-mediated Endocytosis Response To Wounding Regulation Of Signaling Smooth Muscle Cell Migration Response To Stimulus Positive Regulation Of Blood Coagulation Cell Migration Regulation Of Cellular Protein Metabolic Process Platelet Activation Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Muscle Cell Migration Acute-phase Response Cell Motility Positive Regulation Of Coagulation Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Cellular Component Movement Regulation Of Cellular Response To Oxidative Stress Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?