SERPINE1 and IGFBP5

Number of citations of the paper that reports this interaction (PMID 9202242)
11

Data Source:
HPRD (in vivo, in vitro)

		SERPINE1	IGFBP5
Gene Name		serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	insulin-like growth factor binding protein 5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Chronological Cell Aging Angiogenesis Platelet Degranulation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Circadian Rhythm Gene Expression Regulation Of Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Cell Proliferation Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Cell Growth Osteoblast Differentiation Glucose Metabolic Process Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Glucose Homeostasis Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Skeletal Muscle Tissue Growth Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Mammary Gland Involution Cellular Response To CAMP Cellular Response To Organic Cyclic Compound
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation Dissolution of Fibrin Clot TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Response to elevated platelet cytosolic Ca2+ ECM proteoglycans TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD4 MH2 Domain Mutants in Cancer	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone
Diseases
GWAS		Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)	Thyroid hormone levels ( 23408906) Visceral fat ( 22589738)
Protein-Protein Interactions		19 interactors: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN	17 interactors: ADAM12 BAG6 F2 FHL2 FN1 IGF1 IGF2 IGFALS KPNB1 PAPPA2 PNO1 RASSF1 SERPINE1 SPP1 TF THBS1 VTN
Entrez ID		5054	3488
HPRD ID		01418	00901
Ensembl ID		ENSG00000106366	ENSG00000115461
Uniprot IDs		P05121	P24593
PDB IDs		1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 9PAI	1BOE 1H59
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Fibrinolysis Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Migration Regulation Of Wound Healing Extracellular Matrix Disassembly Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Abiotic Stimulus Blood Coagulation Hemostasis Acute Inflammatory Response Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress Response To Hypoxia Regulation Of Cell Migration Wound Healing Proteolysis Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Motility Endocytosis Receptor-mediated Endocytosis Response To Wounding Regulation Of Signaling Smooth Muscle Cell Migration Response To Stimulus Positive Regulation Of Blood Coagulation Cell Migration Regulation Of Cellular Protein Metabolic Process Platelet Activation Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Muscle Cell Migration Acute-phase Response Cell Motility Positive Regulation Of Coagulation Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Cellular Component Movement Regulation Of Cellular Response To Oxidative Stress Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion	Platelet Degranulation Platelet Activation Blood Coagulation Hemostasis Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Exocytosis Wound Healing Regulation Of Fibrinolysis Cell Activation Response To Wounding Regulation Of Blood Coagulation Secretion By Cell Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Response To Stress Positive Regulation Of Blood Coagulation Response To Stimulus Regulation Of Wound Healing Regulation Of Cell Adhesion Secretion Positive Regulation Of Coagulation Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Protein Processing Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Regulation Of Protein Processing Negative Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Negative Regulation Of Plasminogen Activation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Wound Healing Cell Differentiation Striated Muscle Cell Differentiation Developmental Process Exocrine Pancreas Development Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase B Signaling Vesicle-mediated Transport Ossification
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	4h antisense autocrine benzopyran c2 igfr igfs indirectly ly294002 messenger modulated morpholinyl myoblast myoblasts p70 p70s6k persisted phenyl phosphatidylinositol pi3 prevents proliferating quiescent rapamycin s6 stably wortmaninn
Tagcloud (Intersection) ?