SERPINE1 and SGTB

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SERPINE1	SGTB
Gene Name		serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding
	Biological Process	Chronological Cell Aging Angiogenesis Platelet Degranulation Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Circadian Rhythm Gene Expression Regulation Of Receptor Activity Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Smooth Muscle Cell Migration Platelet Activation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Regulation Of Cell Proliferation Fibrinolysis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation Dissolution of Fibrin Clot TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Response to elevated platelet cytosolic Ca2+ ECM proteoglycans TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD4 MH2 Domain Mutants in Cancer
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone
Diseases
GWAS		Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		19 interactors: ACTN4 ELANE F2 IGFBP5 KLK2 KRT18 LRP1 LRP1B LRP2 MMP3 ORM1 PLAT PLAU PLG SGTA SGTB UBQLN1 UBQLN4 VTN	7 interactors: EFEMP2 IL6ST LAMP3 RAI2 SERPINE1 TMPO TXNDC12
Entrez ID		5054	54557
HPRD ID		01418	18049
Ensembl ID		ENSG00000106366	ENSG00000197860
Uniprot IDs		P05121	Q96EQ0
PDB IDs		1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 9PAI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Fibrinolysis Regulation Of Blood Coagulation Regulation Of Smooth Muscle Cell Migration Regulation Of Wound Healing Extracellular Matrix Disassembly Vesicle-mediated Transport Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Abiotic Stimulus Blood Coagulation Hemostasis Acute Inflammatory Response Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Response To Stress Response To Hypoxia Regulation Of Cell Migration Wound Healing Proteolysis Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Motility Endocytosis Receptor-mediated Endocytosis Response To Wounding Regulation Of Signaling Smooth Muscle Cell Migration Response To Stimulus Positive Regulation Of Blood Coagulation Cell Migration Regulation Of Cellular Protein Metabolic Process Platelet Activation Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Adhesion Muscle Cell Migration Acute-phase Response Cell Motility Positive Regulation Of Coagulation Regulation Of Signal Transduction Leukocyte Migration Negative Regulation Of Cellular Component Movement Regulation Of Cellular Response To Oxidative Stress Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion	Negative Regulation Of Vascular Wound Healing Interleukin-11-mediated Signaling Pathway Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Interleukin-27-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Chronological Cell Aging Negative Regulation Of Interleukin-6-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Regulation Of Vascular Wound Healing Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Negative Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Plasminogen Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Inflammatory Response Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Fibrinolysis Regulation Of Monocyte Chemotaxis Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cytokine Production Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	absent adjacent blotting clinicopathologic cochaperone cognate diverse favorable gender glutamine hbsag hccs hepatocellular histological homology hsc70 immunochemistry isoform notable paracancerous parameter prognosis recruit repeat terminus tetratricopeptide ubiquitously univariate
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 thbs1 thbs2	absent adjacent blotting clinicopathologic cochaperone cognate diverse favorable gender glutamine hbsag hccs hepatocellular histological homology hsc70 immunochemistry isoform notable paracancerous parameter prognosis recruit repeat terminus tetratricopeptide ubiquitously univariate
Tagcloud (Intersection) ?