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SERPINE1 and UBQLN4
Number of citations of the paper that reports this interaction (PMID
16713569
)
214
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SERPINE1
UBQLN4
Gene Name
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
ubiquilin 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Protease Binding
Serine-type Endopeptidase Inhibitor Activity
Receptor Binding
Protein Binding
Protein Binding
Polyubiquitin Binding
Identical Protein Binding
Biological Process
Chronological Cell Aging
Angiogenesis
Platelet Degranulation
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Blood Coagulation
Circadian Rhythm
Gene Expression
Regulation Of Receptor Activity
Negative Regulation Of Plasminogen Activation
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Smooth Muscle Cell Migration
Platelet Activation
Positive Regulation Of Blood Coagulation
Negative Regulation Of Blood Coagulation
Extracellular Matrix Organization
Negative Regulation Of Cell Migration
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Leukotriene Production Involved In Inflammatory Response
Regulation Of Cell Proliferation
Fibrinolysis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Negative Regulation Of Fibrinolysis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Wound Healing
Cellular Response To Lipopolysaccharide
Positive Regulation Of Monocyte Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Smooth Muscle Cell-matrix Adhesion
Negative Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways
Loss of Function of TGFBR2 in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Platelet degranulation
Dissolution of Fibrin Clot
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Generic Transcription Pathway
Response to elevated platelet cytosolic Ca2+
ECM proteoglycans
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Platelet activation, signaling and aggregation
BMAL1:CLOCK,NPAS2 activates circadian gene expression
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Alteplase
Urokinase
Reteplase
Anistreplase
Tenecteplase
Drotrecogin alfa
Troglitazone
Diseases
GWAS
Plasminogen activator inhibitor type 1 levels (PAI-1) (
22990020
)
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
19 interactors:
ACTN4
ELANE
F2
IGFBP5
KLK2
KRT18
LRP1
LRP1B
LRP2
MMP3
ORM1
PLAT
PLAU
PLG
SGTA
SGTB
UBQLN1
UBQLN4
VTN
157 interactors:
ADAM33
ADPGK
AGR2
ANKRD13D
AREG
ARL4C
ATPIF1
ATXN1
BAG6
BPIFA1
C11orf49
C1orf94
C1QTNF1
CACNA1G
CCDC107
CCDC134
CCDC136
CCDC14
CCDC33
CCL21
CD99
CDSN
CEND1
COL8A1
COPB1
CPSF6
CRIPT
CSTF2
CSTF2T
CTSB
CYB5R1
DAZAP2
DKK3
DMPK
DNAJB11
DTX2
EAPP
EDN1
EEF1A1
EFEMP2
ELF5
EPDR1
ERP27
ERP29
FA2H
FGFBP1
FKBP2
FKBP7
FZD7
GABRD
GDI1
GKAP1
GPX7
HAVCR1
HGS
HK2
HSPA13
HSPA5
IGFBP6
IGHM
IGLC1
IMMT
IMPDH2
ITPRIPL1
KLHL26
KLHL42
LAT2
MDK
MDM2
MIEF2
MIF4GD
MLLT6
MOAP1
MYDGF
NAE1
NME3
NOMO1
NOMO3
NOTCH2NL
NPHP1
NPPA
NXF1
OAT
ORC5
PBXIP1
PCDH17
PCDH8
PDIA5
PDLIM7
PELI2
PICK1
PIN1
PIP4K2B
PLA2G16
PMEPA1
PNMA1
PPIB
PPIC
PRL
PRPF40A
PSMD4
PTN
PTPRN
PTPRN2
QSOX1
RAD23A
RAI2
RBM10
RIC8A
RNF11
RNPS1
ROBO2
RPN1
RSRC2
RUNX1T1
RXRA
SCAF1
SCG2
SCG5
SCMH1
SEMG1
SERPINE1
SERPINH1
SERPINI2
SMAD3
SMAD9
SMARCB1
SPAG8
SPINT1
SPP1
SRGN
SRSF2
STAM2
STMN1
SUPT20H
TFF1
TGFB1I1
TNFRSF14
TNRC6B
TRAF2
TRIB2
TRIM32
UBQLN1
UBQLN2
UBR7
UNC119
UROS
USMG5
VIP
WAC
YWHAQ
ZBTB22
ZDHHC3
ZFPM2
ZG16
ZG16B
ZNF205
Entrez ID
5054
56893
HPRD ID
01418
05670
Ensembl ID
ENSG00000106366
ENSG00000160803
Uniprot IDs
P05121
B4DZF6
Q9NRR5
PDB IDs
1A7C
1B3K
1C5G
1DB2
1DVM
1DVN
1LJ5
1OC0
3CVM
3EOX
3PB1
3Q02
3Q03
3R4L
3UT3
4AQH
9PAI
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Blood Coagulation
Negative Regulation Of Coagulation
Negative Regulation Of Wound Healing
Fibrinolysis
Regulation Of Blood Coagulation
Regulation Of Smooth Muscle Cell Migration
Regulation Of Wound Healing
Extracellular Matrix Disassembly
Vesicle-mediated Transport
Extracellular Matrix Organization
Extracellular Structure Organization
Positive Regulation Of Wound Healing
Regulation Of Locomotion
Regulation Of Cellular Component Movement
Response To Abiotic Stimulus
Blood Coagulation
Hemostasis
Acute Inflammatory Response
Negative Regulation Of Fibrinolysis
Regulation Of Fibrinolysis
Regulation Of Body Fluid Levels
Response To Stress
Response To Hypoxia
Regulation Of Cell Migration
Wound Healing
Proteolysis
Negative Regulation Of Smooth Muscle Cell Migration
Regulation Of Cell Motility
Endocytosis
Receptor-mediated Endocytosis
Response To Wounding
Regulation Of Signaling
Smooth Muscle Cell Migration
Response To Stimulus
Positive Regulation Of Blood Coagulation
Cell Migration
Regulation Of Cellular Protein Metabolic Process
Platelet Activation
Negative Regulation Of Protein Metabolic Process
Regulation Of Cell-substrate Adhesion
Muscle Cell Migration
Acute-phase Response
Cell Motility
Positive Regulation Of Coagulation
Regulation Of Signal Transduction
Leukocyte Migration
Negative Regulation Of Cellular Component Movement
Regulation Of Cellular Response To Oxidative Stress
Regulation Of Protein Metabolic Process
Negative Regulation Of Locomotion
Regulation Of Cellular Process
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Signaling
Signal Transduction
Cell Communication
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Regulation Of Cell Death
Regulation Of Apoptotic Process
Regulation Of Cell Proliferation
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transport
Organ Development
Positive Regulation Of Mitochondrion Organization
Regulation Of Cellular Localization
Regulation Of Proteolysis
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Developmental Process
Response To Organic Substance
Tissue Development
Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Behavior
Regulation Of Phosphorus Metabolic Process
System Development
Protein Peptidyl-prolyl Isomerization
Regulation Of Signaling
Negative Regulation Of Cell Proliferation
Regulation Of Body Fluid Levels
Regulation Of Chemotaxis
Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorylation
Cellular Localization
Defense Response
Regulation Of Mitochondrion Organization
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Cellular Component Organization
Tagcloud
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
map2k7
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
thbs1
thbs2
Tagcloud (Difference)
?
bag1
bcl2l2
bctis
ccna2
comprehend
ctsb
deregulations
fgf1
fosl1
gabrp
gsn
hnepi
id2
il6r
itgb4
klf5
klk5
map2k7
microdissected
ngfb
ngfr
ontological
pappa
plau
scgb1d2
scgb2a1
thbs1
thbs2
Tagcloud (Intersection)
?