RTL8B and ALAS1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		RTL8B	ALAS1
Description		retrotransposon Gag like 8B	5'-aminolevulinate synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol Membrane
	Molecular Function	Protein Binding	5-aminolevulinate Synthase Activity Protein Binding Transferase Activity Acyltransferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process		Response To Hypoxia Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Response To Herbicide Response To Nickel Cation Response To Nutrient Levels Response To Cobalt Ion Cellular Response To Insulin Stimulus Tetrapyrrole Biosynthetic Process Response To Gonadotropin Hemoglobin Biosynthetic Process Response To Ethanol Heme O Biosynthetic Process Erythrocyte Development Response To CAMP Response To Platinum Ion Response To Bile Acid
Pathways			Heme biosynthesis PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glycine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		11 interacting genes: ALAS1 CCDC102B KRT13 PEG10 RIN3 SDCBP SPG21 TADA2A UBC UBQLN1 UBQLN2	54 interacting genes: BCL7A C2orf42 C8orf33 CAP2 CCHCR1 CDC73 CDK5 CDKN1A CERK COBL EP400 FBXL8 FXR1 GNL3L GRXCR1 HSBP1L1 JRK KIF9 KLHL35 LONRF1 LRRC45 MTFR2 MTSS2 NUDT3 OXTR PIBF1 PIK3CB PLAU POLDIP2 PPL RAP1B RNF168 RTL8B SH2D4A SNRPB2 SNX20 STAMBP SUMO2 TCEA2 TEKT4 TK1 TMSB10 TMSB4X TMSB4XP1 TMSB4XP2 TMSB4XP6 TTC23 USP20 UTP14C WIPF1 ZFYVE26 ZMAT1 ZNF175 ZNF564
Entrez ID		441518	211
HPRD ID		19134	00505
Ensembl ID		ENSG00000212747	ENSG00000023330
Uniprot IDs		Q17RB0	B4DVA0 P13196 Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Receptor Internalization Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Regulation Of Receptor Internalization Regulation Of Receptor-mediated Endocytosis Positive Regulation Of ERAD Pathway Negative Regulation Of Transport Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Interleukin-5 Receptor Complex Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Mast Cell Chemotaxis Cytosol Regulation Of Endocytosis 5-aminolevulinate Synthase Activity Response To Nickel Cation Interleukin-5 Receptor Binding Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Extracellular Vesicle Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Vesicle-mediated Intercellular Transport Autophagosome Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Response To Platinum Ion Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Response To Herbicide Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Actin Monomer Binding
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