H3-5 and PRMT6

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		H3-5	PRMT6
Description		H3.5 histone	protein arginine methyltransferase 6
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GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome	Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Protein Heterodimerization Activity	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity
	Biological Process	Positive Regulation Of Cell Growth	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways			RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Adult body size ( 32376654) Blood pressure measurement (low sodium intervention) ( 24165912) Intelligence ( 22449649) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Non-obstructive azoospermia ( 22197933) Obesity (early onset extreme) ( 23563609) Refractive error ( 32231278) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome ( 29029846) Sex hormone-binding globulin levels ( 22829776) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1	90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9
Entrez ID		440093	55170
HPRD ID		18443	10505
Ensembl ID		ENSG00000188375	ENSG00000198890
Uniprot IDs		Q6NXT2	Q96LA8
PDB IDs		2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3 7TRL 7W67 7W6I 7W6J 7W6L 7Y0I 7ZEZ 8Q1G 8Q1H 8Q1J 8RBX 8SR6 8T4F 8T4R 8ZXC 9C0O 9DZN	4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Histone Methyltransferase Activity Methyltransferase Activity Methylation Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Nucleosome Assembly Protein-arginine N-methyltransferase Activity Nucleosome Organization Histone Binding Histone H3K4 Methyltransferase Activity Protein-DNA Complex Assembly Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Transferase Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K36 Dimethyltransferase Activity Nucleoplasm Peptidyl-arginine Methylation Protein-arginine Omega-N Monomethyltransferase Activity Nucleus Chromosome Histone H4 Methyltransferase Activity Transcription Corepressor Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Histone H3K36 Methyltransferase Activity Histone H3K9 Demethylase Activity Protein-containing Complex Assembly Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of RNA Metabolic Process Positive Regulation Of ATP-dependent Activity Histone Demethylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Nuclear Androgen Receptor Binding Histone Methyltransferase Complex S-adenosylmethionine-dependent Methyltransferase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP-dependent Activity	Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus
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