H3-5 and KDM4B

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		H3-5	KDM4B
Description		H3.5 histone	lysine demethylase 4B
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GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Nucleosomal DNA Binding Protein Heterodimerization Activity	Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity
	Biological Process	Positive Regulation Of Cell Growth	Chromatin Organization Chromatin Remodeling Brain Development Regulation Of Gene Expression
Pathways			HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Granulocyte percentage of myeloid white cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528) Walking pace ( 33128006)
Interacting Genes		15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1	2 interacting genes: H3-5 MED10
Entrez ID		440093	23030
HPRD ID		18443	11056
Ensembl ID		ENSG00000188375	ENSG00000127663
Uniprot IDs		Q6NXT2	A0A0C4DFL8 F5GX28 O94953
PDB IDs		2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3 7TRL 7W67 7W6I 7W6J 7W6L 7Y0I 7ZEZ 8Q1G 8Q1H 8Q1J 8RBX 8SR6 8T4F 8T4R 8ZXC 9C0O 9DZN	4LXL 4UC4 7JM5 9H44
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Histone Methyltransferase Activity Methyltransferase Activity Methylation Histone H3 Methyltransferase Activity Histone H4R3 Methyltransferase Activity Nucleosome Assembly Protein-arginine N-methyltransferase Activity Nucleosome Organization Histone Binding Histone H3K4 Methyltransferase Activity Protein-DNA Complex Assembly Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Transferase Activity Regulation Of Signal Transduction By P53 Class Mediator Histone H3K36 Dimethyltransferase Activity Nucleoplasm Peptidyl-arginine Methylation Protein-arginine Omega-N Monomethyltransferase Activity Nucleus Chromosome Histone H4 Methyltransferase Activity Transcription Corepressor Activity Histone H3K4 Trimethyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Histone H3K36 Methyltransferase Activity Histone H3K9 Demethylase Activity Protein-containing Complex Assembly Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Protein-containing Complex Organization Regulation Of RNA Metabolic Process Positive Regulation Of ATP-dependent Activity Histone Demethylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Nuclear Androgen Receptor Binding Histone Methyltransferase Complex S-adenosylmethionine-dependent Methyltransferase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of ATP-dependent Activity
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