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H3F3C and KDM1A
Number of citations of the paper that reports this interaction (PMID
23455924
)
3
Data Source:
BioGRID
(two hybrid)
H3F3C
KDM1A
Gene Name
H3 histone, family 3C
lysine (K)-specific demethylase 1A
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Nuclear Euchromatin
Nuclear Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Molecular Function
Nucleosomal DNA Binding
Protein Heterodimerization Activity
RNA Polymerase II Transcription Factor Binding
P53 Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Oxidoreductase Activity
Enzyme Binding
Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Demethylase Activity
Histone Demethylase Activity
Histone Demethylase Activity (H3-K4 Specific)
Histone Demethylase Activity (H3-K9 Specific)
Histone Demethylase Activity (H3-dimethyl-K4 Specific)
MRF Binding
Transcription Regulatory Region DNA Binding
Flavin Adenine Dinucleotide Binding
Androgen Receptor Binding
Biological Process
Positive Regulation Of Cell Growth
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
Chromatin Organization
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Demethylation
Blood Coagulation
Cell Proliferation
Regulation Of Primitive Erythrocyte Differentiation
Pituitary Gland Development
Granulocyte Differentiation
Negative Regulation Of Protein Binding
Histone H3-K9 Demethylation
Histone H3-K4 Demethylation
Negative Regulation Of DNA Binding
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Hormone Biosynthetic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Muscle Cell Development
Oxidation-reduction Process
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
Pathways
Chromatin modifying enzymes
HDACs deacetylate histones
Chromatin organization
HDMs demethylate histones
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions
12 interactors:
KAT6A
KDM1A
KDM4B
NASP
PRMT5
PRMT6
PRMT7
SETMAR
SMYD1
SMYD3
SUV39H1
WHSC1L1
219 interactors:
AKAP9
ANKEF1
AP1G2
AR
ARHGAP15
ARHGAP29
ASB10
ASB3
ASCC2
ATP5J2
ATP6V1B1
BAHD1
BAIAP2
BATF
BCAT1
BLZF1
BMP3
BRCA1
C16orf59
C17orf82
C18orf54
C4orf17
C8orf48
C8orf74
CCDC121
CCDC14
CCDC151
CCDC155
CCDC172
CCDC37
CCDC53
CCDC74A
CCDC74B
CCDC90B
CDC23
CDC5L
CDCA4
CDCA5
CENPQ
CEP162
CEP70
CRBN
CRLF3
CTBP1
DBF4B
DNAJA3
DNTTIP1
DYX1C1
E2F1
ECI2
ELOF1
EXOC1
EZH2
FAM9A
FIGNL1
FYCO1
FYN
GABPB2
GDF9
GLYR1
GOLGA2
GPATCH2L
GSTCD
GTPBP2
H3F3C
HAUS1
HAUS3
HAUS6
HDAC1
HESX1
HIST1H3A
HIST2H3C
HIST3H3
HOXA1
ID2
IFI35
IGFBP4
IK
IKBIP
IL16
IMMT
INTS2
ISL1
ITGB3BP
ITSN2
KANSL1
KDM5B
KIAA0408
KIFC3
KLC3
KLF3
KLHDC4
KRT17
KRT19
KRT222
KRT33B
KRT38
KRT6A
KRT6B
KRT7
L3MBTL3
LENG8
LOXL4
MALT1
MBD3
MBD4
MCPH1
MCRS1
MLC1
MNS1
MTA3
MTF2
MTMR9
MTO1
MYC
MYLIP
NBPF15
NDUFA8
NDUFS1
NECAB2
NEFL
NF2
NMI
NOSTRIN
NR1H2
NR1H3
NR2C2
NR2E1
OFCC1
OIP5
OPA3
OTUB1
PDCD5
PDE4DIP
PEX7
PHC2
PHF19
PHF20L1
PHF21A
PMF1
PNKP
PPARD
PPP1R12A
PRDM1
PRIM2
PSMC1
PSMC3
RASSF1
RASSF2
RASSF8
RCOR1
RCOR3
RNF10
RPRD1A
SAMD3
SEPT6
SERGEF
SETDB1
SF3B2
SH3GLB2
SLU7
SMAD9
SMARCD1
SMN1
SNF8
SNX15
SOCS6
SPATA22
SPATA24
SPICE1
SPRY2
SPSB1
SPZ1
SRGAP3
SSX2IP
STAT3
STX11
STX19
SUMO1
SUMO2
SUV39H1
TACC1
TADA3
TAL1
TDO2
TERF1
TEX35
TEX9
TNFAIP1
TNNT2
TP53
TRAF4
TRIM39
TRIM54
TSACC
TSC1
TTC33
UBA3
UCHL5
UNC119
UNKL
USP28
VPS11
VPS37A
WBSCR27
WDR83
YEATS4
ZBTB24
ZCCHC17
ZFP28
ZNF280A
ZNF333
ZNF436
ZNF451
ZNF480
ZNF581
ZNF641
ZNF71
ZNF829
Entrez ID
440093
23028
HPRD ID
18443
09800
Ensembl ID
ENSG00000188375
ENSG00000004487
Uniprot IDs
Q6NXT2
O60341
PDB IDs
3KV4
2COM
2DW4
2EJR
2H94
2HKO
2IW5
2L3D
2UXN
2UXX
2V1D
2X0L
2XAF
2XAG
2XAH
2XAJ
2XAQ
2XAS
2Y48
2Z3Y
2Z5U
3ABT
3ABU
3ZMS
3ZMT
3ZMU
3ZMV
3ZMZ
3ZN0
3ZN1
Enriched GO Terms of Interacting Partners
?
Chromatin Modification
Chromatin Organization
Chromosome Organization
Histone Modification
Histone Methylation
Protein Methylation
Methylation
Organelle Organization
Peptidyl-amino Acid Modification
Histone Lysine Methylation
Peptidyl-lysine Methylation
Peptidyl-lysine Modification
Histone H4-R3 Methylation
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Peptidyl-arginine N-methylation
Histone Arginine Methylation
Peptidyl-arginine Methylation
Cellular Protein Modification Process
Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
RNA Biosynthetic Process
Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Cellular Protein Metabolic Process
Regulation Of RNA Biosynthetic Process
RNA Metabolic Process
Regulation Of RNA Metabolic Process
Gene Expression
Regulation Of Gene Expression
Cellular Macromolecular Complex Assembly
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Peptidyl-lysine Dimethylation
Protein Metabolic Process
Nucleosome Assembly
Regulation Of Metabolic Process
Chromatin Assembly
Cell Cycle
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Organelle Organization
Gene Expression
RNA Metabolic Process
Mitotic Cell Cycle
Cell Cycle Process
Regulation Of Gene Expression
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Mitotic Cell Cycle Process
Chromosome Organization
Negative Regulation Of Biosynthetic Process
Chromatin Organization
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Chromatin Modification
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Process
Negative Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Regulation Of Chromosome Organization
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Regulation Of Cellular Component Organization
Biosynthetic Process
Regulation Of Cellular Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Developmental Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Protein Modification By Small Protein Conjugation
Tagcloud
?
aml
blasts
ccaat
confers
corepressor
corest
demethylase
demethylates
depleted
di
engrafted
engraftment
exhibiting
h3k4me3
hdi
lsd1
mark
me2
mono
npm1
oncoproteins
pan
panobinostat
permissive
ps
shrna
sp2509
synergistically
warranting
Tagcloud (Difference)
?
aml
blasts
ccaat
confers
corepressor
corest
demethylase
demethylates
depleted
di
engrafted
engraftment
exhibiting
h3k4me3
hdi
lsd1
mark
me2
mono
npm1
oncoproteins
pan
panobinostat
permissive
ps
shrna
sp2509
synergistically
warranting
Tagcloud (Intersection)
?