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SMAD1 and SQSTM1
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
SMAD1
SQSTM1
Description
SMAD family member 1
sequestosome 1
Image
GO Annotations
Cellular Component
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Membrane
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Phagophore Assembly Site
P-body
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosome
Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Cytoplasmic Vesicle
Intracellular Membraneless Organelle
Amphisome
Autolysosome
Synapse
Extracellular Exosome
Sperm Midpiece
Lewy Body
Glutamatergic Synapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
Signaling Receptor Activity
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Ubiquitin-modified Protein Reader Activity
Protein Sequestering Activity
Molecular Sequestering Activity
Molecular Condensate Scaffold Activity
Biological Process
MAPK Cascade
Ossification
Osteoblast Differentiation
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Cardiac Conduction System Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Gamete Generation
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Cell Differentiation
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Developmental Process
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Stem Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Dendrite Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Sprouting Angiogenesis
Anti-Mullerian Hormone Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Pexophagy
Temperature Homeostasis
Immune System Process
Response To Ischemia
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Import Into Nucleus
Autophagy
Apoptotic Process
Endosome Organization
Intracellular Protein Localization
Positive Regulation Of Autophagy
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To Stress
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Brown Fat Cell Proliferation
Protein K63-linked Ubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Energy Homeostasis
Response To Mitochondrial Depolarisation
Negative Regulation Of Ferroptosis
Membraneless Organelle Assembly
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Cardiogenesis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Neddylation
Interleukin-1 signaling
Pexophagy
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
Drugs
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Lung function (FEV1) (
30061609
)
Malaria (
31844061
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Red cell distribution width (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
163 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APC
APP
AR
ARHGEF6
ARL4D
AXIN2
BMPR1A
BTBD2
BTG2
BUB1
CAMSAP1
CCND1
CDK7
CDK9
CHMP3
CILK1
COL4A1
CREBBP
CTNNA1
DACH1
DLC1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
EPN2
ERBB2
ERBIN
EWSR1
FBXL12
FBXO30
FBXW7
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MLH1
MLH3
MRTFB
MSH2
MUTYH
NAT9
NEDD4
NEDD9
NEUROG1
NFE2L2
NKX3-2
NOTCH2
NRAS
OAZ1
OAZ3
PAK1
PARD3
PDGFRL
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PTPN12
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TAPT1
TCF20
TET2
TGFBR1
TLR2
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
108 interacting genes:
ACAD10
AIM2
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNF
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
IKBKB
IRAK1
KAT5
KCNAB2
KEAP1
KPNA4
LCK
LINC01554
LRRK2
MALT1
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MOAP1
MTDH
NBR1
NCOR1
NEDD4
NEDD8
NLRP6
NR2F2
NTRK1
NTRK2
NTRK3
OGT
PADI1
PAWR
PELI1
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RNF26
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIM27
TRIM55
TRIM63
TTN
UBA52
UBB
ULK2
USP8
VANGL2
VAPB
WBP4
WDR81
WEE2-AS1
WWP2
YWHAZ
Entrez ID
4086
8878
HPRD ID
03356
03319
Ensembl ID
ENSG00000170365
ENSG00000161011
Uniprot IDs
Q15797
Q13501
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
7R1O
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
SMAD Binding
Regulation Of Gene Expression
Pattern Specification Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Regionalization
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Negative Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Multicellular Organismal Process
Chromatin Binding
DNA Binding
Cellular Developmental Process
I-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Developmental Process
Embryonic Morphogenesis
Negative Regulation Of Developmental Process
Negative Regulation Of Metabolic Process
Regulation Of Multicellular Organismal Development
Anatomical Structure Morphogenesis
Intracellular Signal Transduction
Regulation Of Signal Transduction
Response To Stress
Regulation Of Cell Communication
Regulation Of Signaling
Cytoplasm
Signal Transduction
Positive Regulation Of Metabolic Process
Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Positive Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Cellular Response To Stress
Regulation Of Apoptotic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Macromolecule Biosynthetic Process
Response To Growth Factor
Transferase Activity
Intracellular Signaling Cassette
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Protein-containing Complex
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
MAPK Cascade
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Growth Factor Stimulus
Cellular Response To Oxygen-containing Compound
Regulation Of Protein Metabolic Process
Kinase Activity
Modification-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Serine/threonine Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
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