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SMAD1 and CDK9
Number of citations of the paper that reports this interaction (PubMedID
19914168
)
59
Data Source:
BioGRID
(enzymatic study)
SMAD1
CDK9
Description
SMAD family member 1
cyclin dependent kinase 9
Image
GO Annotations
Cellular Component
Chromatin
Male Germ Cell Nucleus
Nucleus
Nuclear Inner Membrane
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Membrane
Protein-containing Complex
SMAD Protein Complex
Homomeric SMAD Protein Complex
Heteromeric SMAD Protein Complex
Nucleus
Nucleoplasm
Cytoplasm
Transcription Elongation Factor Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Membrane
PML Body
Cytoplasmic Ribonucleoprotein Granule
P-TEFb Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
DEAD/H-box RNA Helicase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
Primary MiRNA Binding
Nucleotide Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Binding
DNA Binding
Chromatin Binding
Transcription Elongation Factor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Transferase Activity
SnRNA Binding
Protein Kinase Binding
7SK SnRNA Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Ossification
Osteoblast Differentiation
Ureteric Bud Development
Mesodermal Cell Fate Commitment
Osteoblast Fate Commitment
Cardiac Conduction System Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Inflammatory Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Gamete Generation
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Embryonic Pattern Specification
Positive Regulation Of Gene Expression
Cell Differentiation
BMP Signaling Pathway
Midbrain Development
Hindbrain Development
Primary MiRNA Processing
Developmental Process
Homeostatic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Stem Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Cartilage Development
Cardiac Muscle Cell Proliferation
Bone Development
SMAD Protein Signal Transduction
Positive Regulation Of Cartilage Development
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Dendrite Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Sprouting Angiogenesis
Anti-Mullerian Hormone Receptor Signaling Pathway
DNA Repair
Regulation Of DNA Repair
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Transcription Elongation By RNA Polymerase II
Protein Phosphorylation
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Replication Fork Processing
Regulation Of MRNA 3'-end Processing
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Host-mediated Activation Of Viral Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Muscle Cell Differentiation
Nucleus Localization
Regulation Of Cell Cycle
Cellular Response To Cytokine Stimulus
Negative Regulation Of Protein Localization To Chromatin
Positive Regulation Of Protein Localization To Chromatin
Transcription Elongation-coupled Chromatin Remodeling
Transcription Pausing By RNA Polymerase II
Pathways
Signaling by BMP
Ub-specific processing proteases
RUNX2 regulates bone development
Cardiogenesis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
Drugs
Alvocidib
Seliciclib
Trilaciclib
Zotiraciclib
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Lung function (FEV1) (
30061609
)
Malaria (
31844061
)
Midgestational cytokine/chemokine levels (maternal genetic effect) (
30134952
)
Panic disorder (
31712720
)
Red cell distribution width (
32888494
)
Response to cognitive-behavioural therapy in anxiety disorder (
26989097
)
Body mass index (
26426971
)
Interacting Genes
163 interacting genes:
ACVR1
ACVRL1
AKR1B1
ANKRD27
AP2A2
APC
APP
AR
ARHGEF6
ARL4D
AXIN2
BMPR1A
BTBD2
BTG2
BUB1
CAMSAP1
CCND1
CDK7
CDK9
CHMP3
CILK1
COL4A1
CREBBP
CTNNA1
DACH1
DLC1
DNMT3L
DVL1
ECSIT
EIF2AK4
ELP3
EP300
EPN2
ERBB2
ERBIN
EWSR1
FBXL12
FBXO30
FBXW7
FHL5
FOXG1
FRZB
GDF6
GLI3
GMEB1
GSC
HBP1
HIPK2
HOXA13
HOXA5
HOXC8
HOXD13
ING2
INPP4A
IRF2BP1
KAT2B
KMT2D
LEF1
LEMD3
LMNA
MAP2K3
MAPK1
MAST4
MBD1
MECOM
MED6
MEN1
MGA
MLH1
MLH3
MRTFB
MSH2
MUTYH
NAT9
NEDD4
NEDD9
NEUROG1
NFE2L2
NKX3-2
NOTCH2
NRAS
OAZ1
OAZ3
PAK1
PARD3
PDGFRL
PIAS1
PIAS4
PIGQ
PLEKHB1
PREB
PSMB4
PSMD1
PSMD11
PTPN12
PUM1
RAB2B
RAB30
RAB34
RAB38
RAB3B
RAB6B
RAC2
RAN
RAP2A
RASD2
RASL12
RFX1
RHEBL1
RHOG
RPS27A
SF3B1
SKI
SKIL
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMARCE1
SMURF1
SMURF2
SNIP1
SNRNP70
SOX5
SQSTM1
SS18L1
STARD13
STK11
STUB1
SUV39H1
TAPT1
TCF20
TET2
TGFBR1
TLR2
TNNT1
TOB1
TRIP6
TTF1
TTF2
UBA52
UBC
UBE2Z
UBXN1
USP45
VEPH1
WDR77
XPC
XPO1
YAP1
YY1
ZBTB44
ZDHHC3
ZEB2
ZNF251
ZNF423
ZNF510
ZNF512B
ZNF521
ZNF76
ZNF8
ZSCAN4
60 interacting genes:
ACTL6A
AFF4
AR
BCL10
CASK
CCNK
CCNT1
CCNT2
CDC34
CDC7
CDK5R1
CEBPA
CTDP1
CTDSPL
CUL1
DHX30
EAF1
EEF1D
FBXO25
GRN
GTF2F1
H2BC21
HEXIM1
HEXIM2
HLTF
HSPA1A
HTATSF1
IL6ST
LBX2
MBP
MDFIC
MED21
MYBL2
NBN
NFKB1
NR2E3
OGT
PIN1
POLR2A
RB1
RCHY1
RELA
RMND5B
RN7SK
SERPINH1
SKP1
SKP2
SMAD1
SMAD2
SMAD3
STAT3
STK36
STUB1
SUPT5H
TAF7
TARBP2
TP53
TRAF2
UBE2A
ZMYM6
Entrez ID
4086
1025
HPRD ID
03356
16016
Ensembl ID
ENSG00000170365
ENSG00000136807
Uniprot IDs
Q15797
P50750
PDB IDs
1KHU
2LAW
2LAX
2LAY
2LAZ
2LB0
2LB1
3Q47
3Q4A
5ZOK
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
6W9E
6Z45
7NWK
8I0L
8K5R
Enriched GO Terms of Interacting Partners
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Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Nucleus
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
SMAD Binding
Regulation Of Gene Expression
Pattern Specification Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Regionalization
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Anterior/posterior Pattern Specification
Negative Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Multicellular Organismal Process
Chromatin Binding
DNA Binding
Cellular Developmental Process
I-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Developmental Process
Embryonic Morphogenesis
Negative Regulation Of Developmental Process
Negative Regulation Of Metabolic Process
Regulation Of Multicellular Organismal Development
Anatomical Structure Morphogenesis
Nucleoplasm
Nucleus
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-templated Transcription
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Binding
Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of DNA-templated Transcription Elongation
Nucleobase-containing Compound Metabolic Process
Macromolecule Biosynthetic Process
Transcription By RNA Polymerase II
Regulation Of Protein Modification Process
Transcription Regulator Complex
Positive Regulation Of MiRNA Metabolic Process
RNA Metabolic Process
Cyclin/CDK Positive Transcription Elongation Factor Complex
7SK SnRNA Binding
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Coactivator Binding
Regulation Of MiRNA Metabolic Process
Negative Regulation Of RNA Metabolic Process
Protein-containing Complex
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Polyubiquitination
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Intracellular Signal Transduction
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