SMAD1 and HOXC8

Number of citations of the paper that reports this interaction (PMID 10224145)
34

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SMAD1	HOXC8
Gene Name		SMAD family member 1	homeobox C8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Nucleoplasm Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Protein Kinase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Response To Organonitrogen Compound Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Wound Healing Response To Drug Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis Cartilage Development Cardiac Muscle Cell Proliferation Bone Development Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Anterior/posterior Pattern Specification Neuron Differentiation Skeletal System Morphogenesis
Pathways		Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		138 interactors: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APP AR ARHGEF6 ARL4D BMPR1A BTBD2 BTG2 CAMSAP1 CDK7 CDK9 CHMP3 COL4A1 DVL1 ECSIT EIF2AK4 ELP3 EP300 ERBB2IP EWSR1 FBXL12 FBXO30 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC GSK3B HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ICK ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MKL2 NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 OAZ1 OAZ3 PAK1 PARD3B PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STUB1 SUV39H1 TCF20 TGFBR1 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	11 interactors: BMPR1A BTG2 DLX2 DLX5 GMNN HOMEZ JUN MSX1 SMAD1 SMAD4 SMAD6
Entrez ID		4086	3224
HPRD ID		03356	00856
Ensembl ID		ENSG00000170365
Uniprot IDs		Q15797	P31273
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Regulation Of Signaling Cellular Response To Growth Factor Stimulus Pattern Specification Process Signaling Transcription From RNA Polymerase II Promoter	BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Pattern Specification Process Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Organ Development Regulation Of RNA Metabolic Process Response To Transforming Growth Factor Beta Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Proliferation Regulation Of Gene Expression Endocardial Cushion Formation Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Organ Morphogenesis Endocardial Cushion Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Epithelium Development Palate Development Embryonic Morphogenesis Embryo Development Negative Regulation Of Cell Proliferation System Development Endocardial Cushion Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Head Development RNA Metabolic Process Nervous System Development Multicellular Organismal Development Cell Differentiation Gene Expression Anatomical Structure Development Cartilage Development Generation Of Neurons Regulation Of Cell Differentiation
Tagcloud ?		balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo	abrogates cdkn1b correlates cyclophilin33 cyp33 downregulation h3k4me3 h4 homeodomain hoxa9 implying isomerase lineage lost mediates mll mutually phd3 preferentially proline reinsertion repression rrm selectivity structurally switch transforming translocations trimethylated
Tagcloud (Difference) ?		balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo	abrogates cdkn1b correlates cyclophilin33 cyp33 downregulation h3k4me3 h4 homeodomain hoxa9 implying isomerase lineage lost mediates mll mutually phd3 preferentially proline reinsertion repression rrm selectivity structurally switch transforming translocations trimethylated
Tagcloud (Intersection) ?