SMAD1 and RAB38

Number of citations: 0 (PubMedID 15761153)
Data Source: HPRD (in vivo)

		SMAD1	RAB38
Name		SMAD family member 1	RAB38, member RAS oncogene family
Structure
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Membrane Protein-containing Complex SMAD Protein Complex Homomeric SMAD Protein Complex Heteromeric SMAD Protein Complex	Mitochondrion Lysosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Lumen Vesicle Melanosome Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Body Phagocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding Primary MiRNA Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding Metal Ion Binding
	Biological Process	MAPK Cascade Ossification Osteoblast Differentiation Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Cardiac Conduction System Development DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Gamete Generation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Embryonic Pattern Specification Positive Regulation Of Gene Expression Cell Differentiation BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Developmental Process Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Proliferation Bone Development SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Sprouting Angiogenesis Anti-Mullerian Hormone Receptor Signaling Pathway	Intracellular Protein Transport Mitochondrion Organization Small GTPase-mediated Signal Transduction Protein Transport Vesicle-mediated Transport Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Melanin Biosynthetic Process Platelet Dense Granule Organization Protein Localization To Membrane Phagosome Acidification Melanosome Assembly Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development Cardiogenesis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
GWAS		HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Lung function (FEV1) ( 30061609 ) Malaria ( 31844061 ) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952 ) Panic disorder ( 31712720 ) Red cell distribution width ( 32888494 ) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097 )	Chloride levels ( 29403010 ) Frontotemporal dementia ( 24943344 ) Gut microbiota (bacterial taxa) ( 27694959 ) LDL cholesterol levels in HIV infection ( 33109212 ) Multiple sclerosis (age of onset) ( 19010793 ) Sodium levels ( 29403010 ) Triiodothyronine levels ( 30824882 ) Urinary albumin-to-creatinine ratio in diabetes ( 26631737 )
Interacting Genes		163 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APC APP AR ARHGEF6 ARL4D AXIN2 BMPR1A BTBD2 BTG2 BUB1 CAMSAP1 CCND1 CDK7 CDK9 CHMP3 CILK1 COL4A1 CREBBP CTNNA1 DACH1 DLC1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 EPN2 ERBB2 ERBIN EWSR1 FBXL12 FBXO30 FBXW7 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MLH1 MLH3 MRTFB MSH2 MUTYH NAT9 NEDD4 NEDD9 NEUROG1 NFE2L2 NKX3-2 NOTCH2 NRAS OAZ1 OAZ3 PAK1 PARD3 PDGFRL PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PTPN12 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TAPT1 TCF20 TET2 TGFBR1 TLR2 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	7 interacting genes: APP BMPR1B SMAD1 SMAD2 SMAD3 SMAD4 TGFBR1
Entrez ID		4086	23682
HPRD ID		03356	05889
Ensembl ID		ENSG00000170365	ENSG00000123892
Uniprot IDs		Q15797	P57729
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK	6HDU 6S5H
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process SMAD Binding Regulation Of Gene Expression Pattern Specification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regionalization Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Multicellular Organismal Process Chromatin Binding DNA Binding Cellular Developmental Process I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process Embryonic Morphogenesis Negative Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis	I-SMAD Binding SMAD Protein Complex Response To Growth Factor Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Pattern Specification Process Trophoblast Cell Migration SMAD Binding Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Gene Expression Co-SMAD Binding Response To Transforming Growth Factor Beta Regulation Of Cartilage Development Primary MiRNA Processing Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regionalization Regulation Of MiRNA Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Extracellular Matrix Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Developmental Growth Osteoblast Differentiation Ameboidal-type Cell Migration R-SMAD Binding Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of RNA Metabolic Process Homomeric SMAD Protein Complex Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Cartilage Development Endoderm Development MiRNA Processing Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Signaling Pathway Anterior/posterior Pattern Specification