SMAD1 and AKR1B1

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD1	AKR1B1
Gene Name		SMAD family member 1	aldo-keto reductase family 1, member B1 (aldose reductase)
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Extracellular Space Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Protein Kinase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Electron Carrier Activity Glyceraldehyde Oxidoreductase Activity
	Biological Process	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Response To Organonitrogen Compound Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Wound Healing Response To Drug Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis Cartilage Development Cardiac Muscle Cell Proliferation Bone Development Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Carbohydrate Metabolic Process C21-steroid Hormone Biosynthetic Process Response To Stress Steroid Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Oxidation-reduction Process
Pathways		Signaling by BMP	Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Metabolism of steroid hormones and vitamin D
Drugs			NADH Sulindac Inhibitor Idd 384 Alpha-D-Glucose-6-Phosphate Alrestatin Fidarestat Fidarestat(Stereoisomer) [3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid Tolrestat N-Acetylalanine Sorbinil IDD552 Hydroxydimethylarsine Oxide 2\'-Monophosphoadenosine 5\'-Diphosphoribose Citric Acid (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid 6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3\'-PYRROLIDINE]-1,2\',3,5\'(2H)-TETRONE 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE IDD594 {[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID
Diseases
GWAS
Protein-Protein Interactions		138 interactors: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APP AR ARHGEF6 ARL4D BMPR1A BTBD2 BTG2 CAMSAP1 CDK7 CDK9 CHMP3 COL4A1 DVL1 ECSIT EIF2AK4 ELP3 EP300 ERBB2IP EWSR1 FBXL12 FBXO30 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC GSK3B HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ICK ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MKL2 NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 OAZ1 OAZ3 PAK1 PARD3B PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STUB1 SUV39H1 TCF20 TGFBR1 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	2 interactors: SHBG SMAD1
Entrez ID		4086	231
HPRD ID		03356	00071
Ensembl ID		ENSG00000170365	ENSG00000085662
Uniprot IDs		Q15797	P15121
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1	1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU 3LBO 3LD5 3LEN 3LEP 3LQG 3LQL 3LZ3 3LZ5 3M0I 3M4H 3M64 3MB9 3MC5 3ONB 3ONC 3P2V 3Q65 3Q67 3RX2 3RX3 3RX4 3S3G 3T42 3U2C 3V35 3V36 3V9Q 4GCA
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Regulation Of Signaling Cellular Response To Growth Factor Stimulus Pattern Specification Process Signaling Transcription From RNA Polymerase II Promoter	Primary Spermatocyte Growth Growth Primary MiRNA Processing Osteoblast Fate Commitment Gamete Generation SMAD Protein Complex Assembly Sexual Reproduction Multicellular Organismal Reproductive Process Mesodermal Cell Fate Commitment Multicellular Organism Reproduction Cardiac Muscle Cell Proliferation Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To BMP Stimulus Reproduction Mesodermal Cell Differentiation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Muscle Tissue Growth Single Organism Reproductive Process Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Dendrite Morphogenesis Gene Silencing By MiRNA Cellular Response To DsRNA Reproductive Process Positive Regulation Of Cartilage Development Posttranscriptional Gene Silencing Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Dendrite Development Gene Silencing By RNA Regulation Of Dendrite Morphogenesis Positive Regulation Of Osteoblast Differentiation Response To DsRNA BMP Signaling Pathway Midbrain Development Mesoderm Formation Developmental Cell Growth Regulation Of Cartilage Development Embryonic Pattern Specification Mesoderm Morphogenesis Positive Regulation Of Ossification Organ Growth Regulation Of Dendrite Development Gene Silencing Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Osteoblast Differentiation
Tagcloud ?		balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo	11beta 9alpha abcc4 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneum proteomics smad2 snail stroma thickness zo	11beta 9alpha abcc4 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc hpgd hpgds infertility pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?		peritoneal