SMAD1 and RPS27A

Number of citations of the paper that reports this interaction (PubMedID 15761153)
0

Data Source:
HPRD (in vivo)

		SMAD1	RPS27A
Description		SMAD family member 1	ribosomal protein S27a
Image
GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Membrane Protein-containing Complex SMAD Protein Complex Homomeric SMAD Protein Complex Heteromeric SMAD Protein Complex	Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Plasma Membrane Endosome Membrane Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Endocytic Vesicle Membrane Vesicle Small-subunit Processome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding Primary MiRNA Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Zinc Ion Binding Protein Tag Activity Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	MAPK Cascade Ossification Osteoblast Differentiation Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Cardiac Conduction System Development DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Gamete Generation Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Embryonic Pattern Specification Positive Regulation Of Gene Expression Cell Differentiation BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Developmental Process Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Cartilage Development Cardiac Muscle Cell Proliferation Bone Development SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Sprouting Angiogenesis Anti-Mullerian Hormone Receptor Signaling Pathway	Cytoplasmic Translation Translation Protein Ubiquitination Modification-dependent Protein Catabolic Process Ribosomal Small Subunit Biogenesis
Pathways		Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development Cardiogenesis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Viral mRNA Translation Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Downstream TCR signaling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Regulation of activated PAK-2p34 by proteasome mediated degradation NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Selenocysteine synthesis Separation of Sister Chromatids Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Stimuli-sensing channels Constitutive Signaling by NOTCH1 HD Domain Mutants FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of innate immune responses to cytosolic DNA Glycogen synthesis Autodegradation of the E3 ubiquitin ligase COP1 Deactivation of the beta-catenin transactivating complex Myoclonic epilepsy of Lafora ABC-family proteins mediated transport TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Regulation of FZD by ubiquitination PINK1-PRKN Mediated Mitophagy N-glycan trimming in the ER and Calnexin/Calreticulin cycle Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Hedgehog 'on' state Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway Negative regulation of MAPK pathway Regulation of necroptotic cell death NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAP3K8 (TPL2)-dependent MAPK1/3 activation HDR through Homologous Recombination (HRR) MAPK6/MAPK4 signaling UCH proteinases UCH proteinases Josephin domain DUBs Ub-specific processing proteases Ovarian tumor domain proteases Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Major pathway of rRNA processing in the nucleolus and cytosol Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Negative regulation of MET activity Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Cyclin D associated events in G1 G2/M Checkpoints Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling VLDLR internalisation and degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell InlA-mediated entry of Listeria monocytogenes into host cells RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN localization Regulation of PTEN stability and activity Neddylation ER Quality Control Compartment (ERQC) Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling Peroxisomal protein import Peroxisomal protein import Interferon alpha/beta signaling Regulation of signaling by CBL Endosomal Sorting Complex Required For Transport (ESCRT) Iron uptake and transport Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Negative regulation of NOTCH4 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Response of EIF2AK4 (GCN2) to amino acid deficiency Prevention of phagosomal-lysosomal fusion Modulation by Mtb of host immune system Alpha-protein kinase 1 signaling pathway Aggrephagy Aggrephagy RAS processing Pexophagy Signaling by CSF1 (M-CSF) in myeloid cells Maturation of protein E SARS-CoV-1 activates/modulates innate immune responses Maturation of protein E Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Negative regulation of FLT3 FLT3 signaling by CBL mutants Regulation of BACH1 activity Signaling by ALK fusions and activated point mutants SARS-CoV-1 modulates host translation machinery TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation SARS-CoV-2 modulates host translation machinery KEAP1-NFE2L2 pathway Regulation of NF-kappa B signaling Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Amyloid fiber formation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Regulation of pyruvate metabolism GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) PD-L1(CD274) glycosylation and translocation to plasma membrane Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Panic disorder ( 31712720) Red cell distribution width ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		163 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APC APP AR ARHGEF6 ARL4D AXIN2 BMPR1A BTBD2 BTG2 BUB1 CAMSAP1 CCND1 CDK7 CDK9 CHMP3 CILK1 COL4A1 CREBBP CTNNA1 DACH1 DLC1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 EPN2 ERBB2 ERBIN EWSR1 FBXL12 FBXO30 FBXW7 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MLH1 MLH3 MRTFB MSH2 MUTYH NAT9 NEDD4 NEDD9 NEUROG1 NFE2L2 NKX3-2 NOTCH2 NRAS OAZ1 OAZ3 PAK1 PARD3 PDGFRL PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PTPN12 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TAPT1 TCF20 TET2 TGFBR1 TLR2 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	41 interacting genes: ACVR1 APP BACH1 BMPR1B CALCOCO2 CDC6 CDK11B DAZAP2 DESI1 DNAJB2 EPN2 EPN3 FAM168A FOXP1 FSHR GGA1 GGA3 KANSL3 LITAF MAST2 MTURN PAXIP1 PLEKHB2 PLSCR4 POLH PTEN RABGEF1 RAD23A RBPMS RNF11 RNF26 SMAD1 SMAD2 SMAD4 SMURF1 SMURF2 TGFBR1 TRAF6 UBQLN1 WBP2 ZNF512B
Entrez ID		4086	6233
HPRD ID		03356	01878
Ensembl ID		ENSG00000170365	ENSG00000143947
Uniprot IDs		Q15797	B2RDW1 P62979
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK	2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6DC6 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6J99 6KFP 6KG6 6KIU 6KIV 6KIW 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6SQO 6SQR 6SQS 6XA1 6Y0G 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7BWD 7F0N 7JQB 7JQC 7K5I 7MQ9 7MQA 7OOJ 7QP6 7QP7 7R4X 7TQL 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNY 8G5Y 8G60 8G61 8G6J 8GLP 8HTC 8HTF 8IFD 8IFE 8IVB 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8T4S 8UKB 8X7I 8X7J 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O 9IJU 9IML 9IPU
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process SMAD Binding Regulation Of Gene Expression Pattern Specification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Differentiation Regionalization Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Multicellular Organismal Process Chromatin Binding DNA Binding Cellular Developmental Process I-SMAD Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process Embryonic Morphogenesis Negative Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis	Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process SMAD Binding Regulation Of Primary Metabolic Process I-SMAD Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Protein Serine/threonine Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction SMAD Protein Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Heteromeric SMAD Protein Complex Activin Receptor Signaling Pathway Endosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex BMP Signaling Pathway Endothelial Cell Activation Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of RNA Biosynthetic Process Regulation Of Protein Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Catabolic Process Homomeric SMAD Protein Complex Regulation Of Protein Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Communication Regulation Of RNA Metabolic Process Positive Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Proteolysis Response To Growth Factor Positive Regulation Of Protein Catabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Signal Transduction Osteoblast Differentiation Positive Regulation Of Protein Metabolic Process Activin Responsive Factor Complex Regulation Of Developmental Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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