SMAD1 and GDF6

Number of citations of the paper that reports this interaction (PMID 15246821)
7

Data Source:
HPRD (in vitro)

		SMAD1	GDF6
Gene Name		SMAD family member 1	growth differentiation factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein Complex	Extracellular Space
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Receptor Signaling Protein Activity Protein Binding Protein Kinase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Response To Organonitrogen Compound Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Wound Healing Response To Drug Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Dendrite Morphogenesis Cartilage Development Cardiac Muscle Cell Proliferation Bone Development Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cell Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Retinal Cell Apoptotic Process
Pathways		Signaling by BMP
Drugs
Diseases
GWAS
Protein-Protein Interactions		138 interactors: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APP AR ARHGEF6 ARL4D BMPR1A BTBD2 BTG2 CAMSAP1 CDK7 CDK9 CHMP3 COL4A1 DVL1 ECSIT EIF2AK4 ELP3 EP300 ERBB2IP EWSR1 FBXL12 FBXO30 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC GSK3B HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ICK ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MKL2 NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 OAZ1 OAZ3 PAK1 PARD3B PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STUB1 SUV39H1 TCF20 TGFBR1 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	5 interactors: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5
Entrez ID		4086	392255
HPRD ID		03356	11002
Ensembl ID		ENSG00000170365	ENSG00000156466
Uniprot IDs		Q15797	Q6KF10
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression RNA Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Regulation Of Signaling Cellular Response To Growth Factor Stimulus Pattern Specification Process Signaling Transcription From RNA Polymerase II Promoter	Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Cartilage Development Regulation Of Ossification Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Pattern Specification Process Skeletal System Development Negative Regulation Of Chondrocyte Proliferation Bone Development Positive Regulation Of Cartilage Development Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction By Phosphorylation Regulation Of Bone Mineralization Osteoblast Fate Commitment Mullerian Duct Regression Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Protein Phosphorylation Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Tissue Development Regulation Of Transcription From RNA Polymerase II Promoter Phosphorylation Intracellular Signal Transduction Tube Development Anatomical Structure Regression Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gastrulation Cellular Response To BMP Stimulus Limb Development Anatomical Structure Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Sex Differentiation Chondrocyte Development Epithelium Development Embryo Development Phosphate-containing Compound Metabolic Process Single Organism Reproductive Process Organ Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Tagcloud ?		balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo	amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened
Tagcloud (Difference) ?		balance cav1 collagens cytokeratin dialytic discontinuation emt eventually fibrosis fluids fn fsp hyperactivation invading junction laminin matrices mcs mek mesothelial pd peritoneal peritoneum proteomics smad2 snail stroma thickness zo	amongst argue bigenic bmp broadened broader degenerative disrupt disrupted effecting endurance gdf6a harboring junctions larval modifier morphogenetic neuromuscular nmj noting progressively siblings sod1 suite synergize vertebrate vertebrates worsened
Tagcloud (Intersection) ?