COL1A2 and PDGFB

Number of citations of the paper that reports this interaction (PubMedID 8900172)
0

Data Source:
BioGRID (pull down, far western blotting)

		COL1A2	PDGFB
Description		collagen type I alpha 2 chain	platelet derived growth factor subunit B
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cell Surface Membrane Basolateral Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Animal Organ Development Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly	Angiogenesis Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Positive Regulation Of Glomerular Filtration Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Response To Wounding Gene Expression Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Paracrine Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells	Platelet degranulation PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Pegpleranib
Diseases		Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)	Glioma Malignant pleural mesothelioma
GWAS		Aging ( 22773346) Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000)
Interacting Genes		31 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN EIF3F FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MESD MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SMARCD1 SPARC TGFBI UBQLN1 UBQLN2 VWF	23 interacting genes: A2M ART1 BCCIP COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 FBXO7 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB PIK3R1 SPARC THBS1
Entrez ID		1278	5155
HPRD ID		00363	01815
Ensembl ID		ENSG00000164692	ENSG00000100311
Uniprot IDs		A0A0S2Z3H5 P08123	A0A384NYY3 P01127
PDB IDs		5CTD 5CTI 5CVA 6JEC	1PDG 3MJG 4HQU 4HQX 4QCI 6T9E
Enriched GO Terms of Interacting Partners?		Collagen Binding Extracellular Matrix Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Extracellular Matrix Extracellular Matrix Structural Constituent Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Integrin Binding Cell Surface Cell-substrate Adhesion Extracellular Region Platelet Alpha Granule Membrane Golgi Lumen Cell-matrix Adhesion Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Migration Extracellular Space Identical Protein Binding Regulation Of Cell Motility Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Fibroblast Proliferation Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Adhesion Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process TRC Complex Positive Regulation Of ERAD Pathway Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Leukocyte Migration Regulation Of Cellular Component Organization Regulation Of Smooth Muscle Cell Migration Integrin AlphaIIb-beta3 Complex Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Body Fluid Levels	Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Extracellular Matrix Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Basement Membrane Anatomical Structure Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Amino Acid Stimulus Phospholipase C Activator Activity Regulation Of Locomotion Response To Amino Acid Enzyme-linked Receptor Protein Signaling Pathway Animal Organ Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Extracellular Region Protease Binding Proteoglycan Binding Skin Development Cell Differentiation Collagen Type I Trimer Collagen V Binding Cellular Developmental Process Collagen Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Kinase Regulator Activity Positive Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly Cell Surface Receptor Signaling Pathway Response To Wounding Vascular Endothelial Growth Factor Binding Basement Membrane Organization Blood Vessel Morphogenesis Cartilage Development Collagen Type XI Trimer Skeletal System Morphogenesis Cell Adhesion
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