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COL1A2 and P4HB
Number of citations of the paper that reports this interaction (PubMedID
10329688
)
0
Data Source:
HPRD
(in vivo)
COL1A2
P4HB
Description
collagen type I alpha 2 chain
prolyl 4-hydroxylase subunit beta
Image
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Exosome
Extracellular Region
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Membrane
Procollagen-proline 4-dioxygenase Complex
Lamellipodium
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Extracellular Exosome
Molecular Function
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Protein-macromolecule Adaptor Activity
Identical Protein Binding
SMAD Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
RNA Binding
Protein Disulfide Isomerase Activity
Actin Binding
Procollagen-proline 4-dioxygenase Activity
Integrin Binding
Protein Binding
Protein-disulfide Reductase Activity
Isomerase Activity
Thiol Oxidase Activity
Enzyme Binding
Protein-containing Complex Binding
Protein Heterodimerization Activity
Biological Process
Skeletal System Development
Blood Vessel Development
Transforming Growth Factor Beta Receptor Signaling Pathway
Rho Protein Signal Transduction
Regulation Of Blood Pressure
Collagen Fibril Organization
Bone Mineralization
Collagen Metabolic Process
Odontogenesis
Skin Morphogenesis
Animal Organ Development
Protein Heterotrimerization
Cellular Response To Amino Acid Stimulus
Extracellular Matrix Assembly
Protein Folding
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Insulin Processing
Protein Folding In Endoplasmic Reticulum
Response To Endoplasmic Reticulum Stress
Interleukin-12-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Positive Regulation Of Cell Adhesion
Positive Regulation Of Viral Entry Into Host Cell
Cellular Response To Hypoxia
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of T Cell Migration
Pathways
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Collagen biosynthesis and modifying enzymes
Insulin processing
Detoxification of Reactive Oxygen Species
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Hedgehog ligand biogenesis
VLDL assembly
Post-translational protein phosphorylation
Chylomicron assembly
LDL remodeling
Interleukin-12 signaling
Interleukin-23 signaling
Drugs
Zinc
Ribostamycin
Copper
Artenimol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS
Aging (
22773346
)
Appendicular lean mass (
33097823
)
Heel bone mineral density (
30598549
)
Immune reponse to smallpox (secreted IL-12p40) (
22610502
)
Intelligence (
22449649
)
Low bone mineral density (hip) (
26235824
)
Low bone mineral density (spine) (
26235824
)
Mean forced vital capacity from 2 exams (
17903307
)
Post bronchodilator FEV1 (
26634245
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Interacting Genes
31 interacting genes:
APP
BGN
CD36
CD44
CD93
COL5A3
DCN
EIF3F
FN1
ITGA2
ITGA2B
ITGB3
KCNIP4
LIG4
LUM
MESD
MMP9
MYOC
P4HB
PDGFA
PDGFB
SERPINB5
SGTA
SGTB
SHBG
SMARCD1
SPARC
TGFBI
UBQLN1
UBQLN2
VWF
54 interacting genes:
CD1D
CHCHD2
CNNM3
COL10A1
COL1A1
COL1A2
CSNK2A2
CST2
EIF2S1
ENO1
ERN1
ERO1A
ERO1B
ESR1
FAM20C
FEZ1
FNDC3B
FZD10
GARIN6
GRN
HNRNPD
ITGB3
KLHL42
KRTAP12-3
KRTAP13-2
KRTAP4-11
KRTAP5-9
KRTAP6-3
KRTAP9-8
LCE1B
LCE2D
LCE4A
LCN2
LGALS9
LINC00839
LRFN4
NECTIN2
NOL4
NTM
ODF1
OGT
P4HA2
P4HA3
PDE4B
PLCXD3
PRNP
PTN
SUMO2
TG
TGFB1
UBQLN1
VWF
YWHAG
ZNF69
Entrez ID
1278
5034
HPRD ID
00363
07181
Ensembl ID
ENSG00000164692
ENSG00000185624
Uniprot IDs
A0A0S2Z3H5
P08123
A0A024R8S5
P07237
PDB IDs
5CTD
5CTI
5CVA
6JEC
1BJX
1MEK
1X5C
2BJX
2K18
3BJ5
3UEM
4EKZ
4EL1
4JU5
6I7S
7ZSC
8EOJ
8GDY
Enriched GO Terms of Interacting Partners
?
Collagen Binding
Extracellular Matrix Binding
Platelet Alpha Granule Lumen
Positive Regulation Of Cell Migration
Extracellular Matrix
Extracellular Matrix Structural Constituent
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Integrin Binding
Cell Surface
Cell-substrate Adhesion
Extracellular Region
Platelet Alpha Granule Membrane
Golgi Lumen
Cell-matrix Adhesion
Positive Regulation Of Fibroblast Proliferation
Regulation Of Cell Migration
Extracellular Space
Identical Protein Binding
Regulation Of Cell Motility
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Fibroblast Proliferation
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Cell Adhesion
Regulation Of Glomerular Mesangial Cell Proliferation
Positive Regulation Of ERK1 And ERK2 Cascade
Angiogenesis
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet-derived Growth Factor Receptor Binding
Regulation Of Cell-substrate Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
TRC Complex
Positive Regulation Of ERAD Pathway
Platelet Alpha Granule
Positive Regulation Of Cell Communication
Positive Regulation Of Leukocyte Migration
Regulation Of Cellular Component Organization
Regulation Of Smooth Muscle Cell Migration
Integrin AlphaIIb-beta3 Complex
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Regulation Of Body Fluid Levels
Protease Binding
Identical Protein Binding
Endoplasmic Reticulum Lumen
Collagen Type I Trimer
Intermediate Filament
Cellular Response To Oxygen-containing Compound
Protein Binding
Extracellular Space
Collagen Fibril Organization
Cellular Response To Glucose Stimulus
Response To Amino Acid
Response To Monosaccharide
Tissue Development
Response To Kainic Acid
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Keratinization
Cellular Response To Carbohydrate Stimulus
Procollagen-proline 4-dioxygenase Activity
Regulation Of Calcium Ion Transmembrane Transport
Regulation Of Response To Tumor Cell
Extracellular Matrix Organization
Extracellular Structure Organization
Response To Oxidative Stress
Thiol Oxidase Activity
Response To Carbohydrate
Intracellular Glucose Homeostasis
Regulation Of Monoatomic Cation Transmembrane Transport
Regulation Of Proteolysis
Odontoblast Differentiation
Biomineral Tissue Development
Keratin Filament
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Regulation Of Leukocyte Mediated Cytotoxicity
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Innate Immune Response
Regulation Of Monoatomic Ion Transmembrane Transport
Response To Xenobiotic Stimulus
Fibrillar Collagen Trimer
Positive Regulation Of Axon Regeneration
Regulation Of Endothelial Cell Migration
Regulation Of Lymphocyte Mediated Immunity
Carbohydrate Homeostasis
Response To Estradiol
Glucose Homeostasis
Negative Regulation Of Translational Initiation
Negative Regulation Of Leukocyte Activation
Regulation Of Innate Immune Response
Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Response To Growth Factor
Positive Regulation Of Proteolysis
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Tagcloud (Intersection)
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