COL1A2 and CD93

Number of citations of the paper that reports this interaction (PubMedID 1377218)
0

Data Source:
HPRD (in vitro)

		COL1A2	CD93
Description		collagen type I alpha 2 chain	CD93 molecule
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Cytoplasmic Vesicle Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Animal Organ Development Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly	Angiogenesis Phagocytosis Cell Adhesion Macrophage Activation Cell-cell Adhesion
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization Enhanced cleavage of VWF variant by ADAMTS13 Enhanced binding of GP1BA variant to VWF multimer:collagen Defective VWF cleavage by ADAMTS13 variant Defective VWF binding to collagen type I Defective binding of VWF variant to GPIb:IX:V Developmental Lineage of Pancreatic Ductal Cells	Neutrophil degranulation
Drugs
Diseases		Osteogenesis imperfecta Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Aging ( 22773346) Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Liver enzyme levels (alanine transaminase) ( 24124411) Obesity-related traits ( 23251661) Venous thromboembolism ( 26888256 31676865)
Interacting Genes		31 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN EIF3F FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MESD MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SMARCD1 SPARC TGFBI UBQLN1 UBQLN2 VWF	25 interacting genes: ARHGAP15 BAG6 C1QA COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COPS5 F12 GIPC1 ITGB1 KIR2DL2 KNG1 MBL2 MMRN2 MSN MYD88 RANBP1 SCYL1 TENT5A UBQLN2
Entrez ID		1278	22918
HPRD ID		00363	00396
Ensembl ID		ENSG00000164692	ENSG00000125810
Uniprot IDs		A0A0S2Z3H5 P08123	Q9NPY3
PDB IDs		5CTD 5CTI 5CVA 6JEC	8A59 8IVD
Enriched GO Terms of Interacting Partners?		Collagen Binding Extracellular Matrix Binding Platelet Alpha Granule Lumen Positive Regulation Of Cell Migration Extracellular Matrix Extracellular Matrix Structural Constituent Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Integrin Binding Cell Surface Cell-substrate Adhesion Extracellular Region Platelet Alpha Granule Membrane Golgi Lumen Cell-matrix Adhesion Positive Regulation Of Fibroblast Proliferation Regulation Of Cell Migration Extracellular Space Identical Protein Binding Regulation Of Cell Motility Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Cell Adhesion Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Fibroblast Proliferation Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Cell Adhesion Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Angiogenesis Extracellular Matrix Structural Constituent Conferring Compression Resistance Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet-derived Growth Factor Receptor Binding Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process TRC Complex Positive Regulation Of ERAD Pathway Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Leukocyte Migration Regulation Of Cellular Component Organization Regulation Of Smooth Muscle Cell Migration Integrin AlphaIIb-beta3 Complex Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Body Fluid Levels	Collagen Trimer Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Extracellular Matrix Structural Constituent Extracellular Matrix Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Platelet-derived Growth Factor Binding Response To Amino Acid Collagen Type I Trimer Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Amino Acid Stimulus Signal Transduction Signaling Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Fibrillar Collagen Trimer Inflammatory Response Glomerular Basement Membrane Development Molecular Adaptor Activity Skin Morphogenesis Regulation Of Proteolysis Endothelial Cell Migration Misfolded Protein Binding Positive Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress Symbiont Cell Surface Protease Binding Cell Migration Involved In Sprouting Angiogenesis Regulation Of ERAD Pathway Killing Of Cells Of Another Organism Angiogenesis Cellular Response To Low-density Lipoprotein Particle Stimulus Killing By Host Of Symbiont Cells Leukocyte Activation Leukocyte Activation Involved In Inflammatory Response Complement Activation, Classical Pathway Cellular Response To Vitamin E Protein Heterotrimerization Neuromuscular Junction Development Basement Membrane Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Wound Healing Zymogen Activation Cellular Response To Lipoprotein Particle Stimulus
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