COL1A2 and TGFBI

Number of citations of the paper that reports this interaction (PMID 12034705)
29

Data Source:
HPRD (in vitro)

		COL1A2	TGFBI
Gene Name		collagen, type I, alpha 2	transforming growth factor, beta-induced, 68kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Protein Binding, Bridging Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Integrin Binding Protein Binding Collagen Binding Extracellular Matrix Binding
	Biological Process	Skeletal System Development Blood Vessel Development Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Odontogenesis Skin Morphogenesis Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Proliferation Extracellular Matrix Organization Response To Stimulus
Pathways		Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors	Amyloids
Drugs
Diseases
GWAS		Aging ( 22773346) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Mean forced vital capacity from 2 exams ( 17903307)
Protein-Protein Interactions		24 interactors: APP BGN CD36 CD44 CD93 COL5A3 DCN FN1 ITGA2 ITGA2B ITGB3 LIG4 LUM MMP9 MYOC P4HB PDGFA PDGFB SGTA SHBG SPARC TGFBI UBQLN1 VWF	10 interactors: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FN1
Entrez ID		1278	7045
HPRD ID		00363	03409
Ensembl ID		ENSG00000164692	ENSG00000120708
Uniprot IDs		P08123	Q15582
PDB IDs			1X3B 2LTB 2VXP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Blood Coagulation Wound Healing Hemostasis Platelet Activation Response To Wounding Regulation Of Body Fluid Levels Cell Activation Exocytosis Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-substrate Adhesion Secretion System Development Cell-matrix Adhesion Anatomical Structure Development Positive Regulation Of Epithelial Cell Migration Extracellular Matrix Disassembly Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Chemotaxis Response To Stress Multicellular Organismal Development Developmental Process Regulation Of Cell Motility Organ Development Locomotion Regulation Of Locomotion Regulation Of Cellular Component Movement Glycosaminoglycan Catabolic Process Regulation Of Epithelial Cell Migration Response To External Stimulus Cell Development Response To Abiotic Stimulus Vesicle-mediated Transport Cell Projection Organization Anatomical Structure Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Axon Guidance Leukocyte Migration Tissue Development Positive Regulation Of Metanephric Mesenchymal Cell Migration	Extracellular Matrix Disassembly Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Axon Guidance Cardiovascular System Development Catabolic Process Platelet Activation Blood Vessel Development Cell Morphogenesis Axonogenesis Vasculature Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cell Differentiation Neuron Projection Morphogenesis Developmental Process Vesicle-mediated Transport Neuron Projection Development Receptor-mediated Endocytosis Generation Of Neurons Cell Projection Morphogenesis Cell Part Morphogenesis System Development Protein Heterotrimerization Neurogenesis Response To Amino Acid Blood Coagulation Neuron Development Hemostasis Cell Development Response To External Stimulus Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Sensory Perception Of Sound Anatomical Structure Development Neuron Differentiation Cell Projection Organization Cellular Response To Acid Chemical
Tagcloud ?		archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound
Tagcloud (Difference) ?		archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound
Tagcloud (Intersection) ?