COL1A2 and LUM

Number of citations of the paper that reports this interaction (PMID 10734230)
24

Data Source:
HPRD (in vitro)

		COL1A2	LUM
Gene Name		collagen, type I, alpha 2	lumican
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Protein Binding, Bridging Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding
	Biological Process	Skeletal System Development Blood Vessel Development Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Odontogenesis Skin Morphogenesis Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus	Carbohydrate Metabolic Process Visual Perception Pathogenesis Response To Organic Cyclic Compound Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cartilage Development Response To Growth Factor
Pathways		Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Aging ( 22773346) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Mean forced vital capacity from 2 exams ( 17903307)	Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		24 interactors: APP BGN CD36 CD44 CD93 COL5A3 DCN FN1 ITGA2 ITGA2B ITGB3 LIG4 LUM MMP9 MYOC P4HB PDGFA PDGFB SGTA SHBG SPARC TGFBI UBQLN1 VWF	5 interactors: ACAN COL1A2 GNAQ MMP14 TRA2B
Entrez ID		1278	4060
HPRD ID		00363	02793
Ensembl ID		ENSG00000164692
Uniprot IDs		P08123	P51884
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Blood Coagulation Wound Healing Hemostasis Platelet Activation Response To Wounding Regulation Of Body Fluid Levels Cell Activation Exocytosis Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-substrate Adhesion Secretion System Development Cell-matrix Adhesion Anatomical Structure Development Positive Regulation Of Epithelial Cell Migration Extracellular Matrix Disassembly Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Chemotaxis Response To Stress Multicellular Organismal Development Developmental Process Regulation Of Cell Motility Organ Development Locomotion Regulation Of Locomotion Regulation Of Cellular Component Movement Glycosaminoglycan Catabolic Process Regulation Of Epithelial Cell Migration Response To External Stimulus Cell Development Response To Abiotic Stimulus Vesicle-mediated Transport Cell Projection Organization Anatomical Structure Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Axon Guidance Leukocyte Migration Tissue Development Positive Regulation Of Metanephric Mesenchymal Cell Migration	Extracellular Matrix Disassembly Skeletal System Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Anatomical Structure Morphogenesis Platelet Activation Organ Morphogenesis Organ Development Skeletal System Morphogenesis Astrocyte Cell Migration Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Chondrocyte Proliferation Keratan Sulfate Catabolic Process Protein Heterotrimerization Regulation Of Melanocyte Differentiation Blood Coagulation Hemostasis Maternal Behavior Craniofacial Suture Morphogenesis Endothelial Cell Proliferation Catabolic Process System Development Negative Regulation Of Focal Adhesion Assembly Blood Vessel Development Regulation Of Catenin Import Into Nucleus Vasculature Development Regulation Of Developmental Pigmentation Keratan Sulfate Biosynthetic Process Cartilage Condensation Regulation Of Body Fluid Levels Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Keratan Sulfate Metabolic Process Wound Healing Neuron Maturation Multicellular Organismal Development Embryonic Morphogenesis Chondrocyte Development Protein Trimerization Positive Regulation Of RNA Splicing Dopamine Receptor Signaling Pathway Anatomical Structure Development Cell Activation
Tagcloud ?		archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner
Tagcloud (Difference) ?		archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner
Tagcloud (Intersection) ?