KLC1 and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		KLC1	MAPK6
Description		kinesin light chain 1	mitogen-activated protein kinase 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	Cytoskeletal Motor Activity Protein Binding Kinesin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	MAPK6/MAPK4 signaling
Drugs			Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB	167 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		3831	5597
HPRD ID		02489	04213
Ensembl ID		ENSG00000126214	ENSG00000069956
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2	Q16659
PDB IDs		3NF1 5OJ8 7AI4 7AIE	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding
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