KLC1 and MAPK8IP1

Number of citations of the paper that reports this interaction (PMID 11238452)
125

Data Source:
HPRD (two hybrid, in vivo)

		KLC1	MAPK8IP1
Gene Name		kinesin light chain 1	mitogen-activated protein kinase 8 interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Axon Growth Cone Ciliary Rootlet Neuronal Cell Body	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Tubulin Binding	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Microtubule-based Movement Blood Coagulation Axon Cargo Transport Metabolic Process Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein Localization To Synapse Stress Granule Disassembly	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APP BNIP2 CCDC114 CLSTN1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 ODF1 PLEKHM2 SNCA SPAG9 YWHAB	25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2
Entrez ID		3831	9479
HPRD ID		02489	05223
Ensembl ID		ENSG00000126214	ENSG00000121653
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 Q07866 Q7RTQ2	E9PBB9 Q6NUQ9 Q9UQF2
PDB IDs		3NF1	2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation JNK Cascade Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Regulation Of JUN Kinase Activity Positive Regulation Of Transferase Activity Cell Morphogenesis Involved In Neuron Differentiation Microtubule-based Movement Positive Regulation Of Catalytic Activity Generation Of Neurons Neuron Projection Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Nervous System Development Positive Regulation Of Stress-activated MAPK Cascade Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Mating Behavior Cell Projection Morphogenesis Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Part Morphogenesis Response To Stress Activation Of JUN Kinase Activity Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Regulation Of Signal Transduction	JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		amyloidogenesis amyloidogenic arise axonal cargos causal collectively concepts controversial defects dysregulation impairs implicate implicates inevitably kinesin klc1ve modifier morihara neurodegeneration perpetuates reciprocal secretory splice splicing transport triggers unbiased vicious	advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse
Tagcloud (Difference) ?		amyloidogenesis amyloidogenic arise axonal cargos causal collectively concepts controversial defects dysregulation impairs implicate implicates inevitably kinesin klc1ve modifier morihara neurodegeneration perpetuates reciprocal secretory splice splicing transport triggers unbiased vicious	advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse
Tagcloud (Intersection) ?