KLC1 and MAPK8IP3

Number of citations of the paper that reports this interaction (PMID 11106729)
76

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		KLC1	MAPK8IP3
Gene Name		kinesin light chain 1	mitogen-activated protein kinase 8 interacting protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Axon Growth Cone Ciliary Rootlet Neuronal Cell Body	Golgi Membrane Cytoplasm Smooth Endoplasmic Reticulum Dendrite Axolemma
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Tubulin Binding	MAP-kinase Scaffold Activity JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Intracellular Protein Transport Microtubule-based Movement Blood Coagulation Axon Cargo Transport Metabolic Process Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein Localization To Synapse Stress Granule Disassembly	In Utero Embryonic Development Activation Of JUN Kinase Activity Axon Guidance Respiratory Gaseous Exchange Protein Localization Post-embryonic Development Regulation Of Gene Expression Vesicle-mediated Transport Forebrain Development Positive Regulation Of Neuron Differentiation Regulation Of JNK Cascade Lung Alveolus Development Lung Morphogenesis
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APP BNIP2 CCDC114 CLSTN1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 ODF1 PLEKHM2 SNCA SPAG9 YWHAB	21 interactors: ARL4D CASP3 KLC1 KLC2 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAF1 RIC8A SRC TLR2 TLR4 TLR9
Entrez ID		3831	23162
HPRD ID		02489	12014
Ensembl ID		ENSG00000126214	ENSG00000138834
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 Q07866 Q7RTQ2	E9PFH7 Q9UPT6
PDB IDs		3NF1
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation JNK Cascade Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Regulation Of JUN Kinase Activity Positive Regulation Of Transferase Activity Cell Morphogenesis Involved In Neuron Differentiation Microtubule-based Movement Positive Regulation Of Catalytic Activity Generation Of Neurons Neuron Projection Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Nervous System Development Positive Regulation Of Stress-activated MAPK Cascade Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Mating Behavior Cell Projection Morphogenesis Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Part Morphogenesis Response To Stress Activation Of JUN Kinase Activity Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Regulation Of Signal Transduction	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade MyD88-dependent Toll-like Receptor Signaling Pathway MAPK Cascade JNK Cascade Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAP Kinase Activity Response To Stress Positive Regulation Of Innate Immune Response Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		amyloidogenesis amyloidogenic arise axonal cargos causal collectively concepts controversial defects dysregulation impairs implicate implicates inevitably kinesin klc1ve modifier morihara neurodegeneration perpetuates reciprocal secretory splice splicing transport triggers unbiased vicious
Tagcloud (Difference) ?		amyloidogenesis amyloidogenic arise axonal cargos causal collectively concepts controversial defects dysregulation impairs implicate implicates inevitably kinesin klc1ve modifier morihara neurodegeneration perpetuates reciprocal secretory splice splicing transport triggers unbiased vicious
Tagcloud (Intersection) ?