KLC1 and KIF5C

Number of citations of the paper that reports this interaction (PMID 10491391)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KLC1	KIF5C
Gene Name		kinesin light chain 1	kinesin family member 5C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Kinesin Complex Microtubule Membrane Cytoplasmic Membrane-bounded Vesicle Axon Growth Cone Ciliary Rootlet Neuronal Cell Body	Cytoplasm Kinesin Complex Microtubule
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Tubulin Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	Intracellular Protein Transport Microtubule-based Movement Blood Coagulation Axon Cargo Transport Metabolic Process Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein Localization To Synapse Stress Granule Disassembly	Organelle Organization Microtubule-based Movement Axon Guidance Protein Localization Metabolic Process Cytoskeleton-dependent Intracellular Transport MRNA Transport
Pathways		MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		18 interactors: APP BNIP2 CCDC114 CLSTN1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 ODF1 PLEKHM2 SNCA SPAG9 YWHAB	7 interactors: CSNK2A1 KIF5A KLC1 KLC3 NCOA2 SNAPIN YWHAG
Entrez ID		3831	3800
HPRD ID		02489	18371
Ensembl ID		ENSG00000126214	ENSG00000168280
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 Q07866 Q7RTQ2	O60282 Q59GB8
PDB IDs		3NF1
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation JNK Cascade Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of JNK Cascade Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Phosphorylation Regulation Of JUN Kinase Activity Positive Regulation Of Transferase Activity Cell Morphogenesis Involved In Neuron Differentiation Microtubule-based Movement Positive Regulation Of Catalytic Activity Generation Of Neurons Neuron Projection Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Neurogenesis Nervous System Development Positive Regulation Of Stress-activated MAPK Cascade Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Axon Guidance Positive Regulation Of Protein Metabolic Process Microtubule-based Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Mating Behavior Cell Projection Morphogenesis Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Part Morphogenesis Response To Stress Activation Of JUN Kinase Activity Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Regulation Of Signal Transduction	Cytoskeleton-dependent Intracellular Transport Axon Cargo Transport Microtubule-based Movement Microtubule-based Transport Movement Of Cell Or Subcellular Component Intracellular Transport Microtubule-based Process Establishment Of Localization In Cell Cellular Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Late Endosome To Lysosome Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Generation Of Neurons Stress Granule Disassembly Neurogenesis Terminal Button Organization Autophagic Vacuole Maturation Protein Localization Neuron Projection Development Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Antigen Neuron Development Positive Regulation Of Intracellular Transport Nervous System Development Antigen Processing And Presentation Synaptic Vesicle Fusion To Presynaptic Membrane Neuron Differentiation Rhythmic Process Cell Projection Organization Synaptic Vesicle Maturation Axon Guidance Cellular Protein Localization Protein Localization To Synapse Transport Protein Transport Anterograde Synaptic Vesicle Transport Blood Coagulation Hemostasis Melanosome Organization Regulation Of Intracellular Transport Pigment Granule Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Protein Localization Organelle Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Anterograde Axon Cargo Transport Endosome To Lysosome Transport Axonogenesis Signaling
Tagcloud ?		amyloidogenesis amyloidogenic arise axonal cargos causal collectively concepts controversial defects dysregulation impairs implicate implicates inevitably kinesin klc1ve modifier morihara neurodegeneration perpetuates reciprocal secretory splice splicing transport triggers unbiased vicious	200x customized dcx depths dync1h1 exome flna funded heterotopia kinesin malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal
Tagcloud (Difference) ?		amyloidogenesis amyloidogenic arise axonal cargos causal collectively concepts controversial defects dysregulation impairs implicate implicates inevitably klc1ve modifier morihara neurodegeneration perpetuates reciprocal secretory splice splicing transport triggers unbiased vicious	200x customized dcx depths dync1h1 exome flna funded heterotopia malformations megalencephaly mosaicism neurodevelopmental neuropsychiatric nodular pachygyria panels periventricular persons polymicrogyria read sanger somatic subcloned subcloning subcortical tubb2b unequal
Tagcloud (Intersection) ?		kinesin