KLC1 and KIF5C

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KLC1	KIF5C
Description		kinesin light chain 1	kinesin family member 5C
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection	Cytoplasm Cytoskeleton Kinesin Complex Microtubule Dendrite Dendrite Cytoplasm Ciliary Rootlet Cell Projection Neuron Projection Neuronal Cell Body Axonal Growth Cone GABA-ergic Synapse Postsynaptic Cytosol Distal Axon Axon Cytoplasm
	Molecular Function	Cytoskeletal Motor Activity Protein Binding Kinesin Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Hydrolase Activity ATP Hydrolysis Activity Apolipoprotein Receptor Binding
	Biological Process	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly	Organelle Organization Microtubule-based Movement Axon Guidance Motor Neuron Axon Guidance Intracellular MRNA Localization Synaptic Vesicle Transport MRNA Transport Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins	Insulin processing
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Chronotype ( 30696823) Mild age-related type 2 diabetes ( 34737425)
Interacting Genes		29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB	10 interacting genes: CSNK2A1 ITSN1 KIF5A KLC1 KLC3 MEOX2 NCOA2 PCNT SNAPIN YWHAG
Entrez ID		3831	3800
HPRD ID		02489	18371
Ensembl ID		ENSG00000126214	ENSG00000168280
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2	O60282 Q59GB8
PDB IDs		3NF1 5OJ8 7AI4 7AIE
Enriched GO Terms of Interacting Partners?		Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade	Kinesin Binding Kinesin Complex Ciliary Rootlet Axo-dendritic Transport Microtubule Microtubule-based Movement Microtubule-based Process Retrograde Axonal Transport Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Microtubule-based Transport Negative Regulation Of Translational Initiation Intracellular Transport Vesicle Transport Along Microtubule Anterograde Axonal Transport Cytoskeletal Motor Activity Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Positive Regulation Of Late Endosome To Lysosome Transport Axonal Transport Neuron Projection Cellular Localization Establishment Of Localization In Cell Organelle Transport Along Microtubule Clathrin-dependent Synaptic Vesicle Endocytosis Protein Localization To Vacuole Vesicle-mediated Transport In Synapse Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Vesicle Localization Protein Kinase C Inhibitor Activity Cellular Response To Thyroglobulin Triiodothyronine Intracellular Protein Localization Cytoplasm Vesicle Localization Positive Regulation Of Caveolin-mediated Endocytosis Protein Transport Positive Regulation Of Aggrephagy Retrograde Neuronal Dense Core Vesicle Transport Somite Specification Positive Regulation Of Intracellular Transport Response To Thyroglobulin Triiodothyronine Terminal Button Organization Sperm Mitochondrial Sheath Assembly Protein-containing Complex Disassembly Intracellular Protein Transport Vacuolar Transport
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