KLC1 and PLEKHM2

Number of citations of the paper that reports this interaction (PubMedID 15905402)
0

Data Source:
HPRD (in vitro)

		KLC1	PLEKHM2
Description		kinesin light chain 1	pleckstrin homology and RUN domain containing M2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Growth Cone Cytoplasmic Vesicle Cell Projection	Cytoplasm Lysosome Lysosomal Membrane Endosome Membrane Membrane
	Molecular Function	Cytoskeletal Motor Activity Protein Binding Kinesin Binding	Protein Binding Kinesin Binding
	Biological Process	Microtubule-based Movement Cell Adhesion Stress Granule Disassembly	Golgi Organization Lysosome Localization Regulation Of Protein Localization Natural Killer Cell Mediated Cytotoxicity
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants Kinesins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 25673413 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061) Smoking behaviour (cigarette pack-years) ( 30679032) Urate levels ( 31578528)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		29 interacting genes: ADRB2 AP1AR APP ATCAY BNIP2 CLSTN1 ERBB2 F2RL1 HSPB1 KIF2A KIF5C KLC2 KRT31 LRSAM1 MAPK6 MAPK8IP1 MAPK8IP2 MAPK8IP3 NIN ODAD1 ODF1 PCM1 PLEKHM2 PTGER4 SNCA SPAG9 TACC3 TSC1 YWHAB	2 interacting genes: KLC1 SLC39A1
Entrez ID		3831	23207
HPRD ID		02489	11440
Ensembl ID		ENSG00000126214	ENSG00000116786
Uniprot IDs		F8W6L3 G3V2E7 G3V3H3 G3V5R9 G5E9S8 Q07866 Q7RTQ2	Q8IWE5
PDB IDs		3NF1 5OJ8 7AI4 7AIE	3CXB 3HW2 3ZFW 8JCA
Enriched GO Terms of Interacting Partners?		Kinesin Binding MAP-kinase Scaffold Activity JUN Kinase Binding Protein Localization To Synapse Positive Regulation Of MAPK Cascade Microtubule-based Process Perinuclear Region Of Cytoplasm Microtubule-based Movement Protein Localization To Cell Junction Anterograde Axonal Protein Transport Protein Transport Along Microtubule Organelle Localization Regulation Of MAPK Cascade MAPK Cascade Regulation Of JNK Cascade Cytoskeleton Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Projection Axonal Growth Cone Axo-dendritic Transport Transport Along Microtubule Ciliary Basal Body Lysosome Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Protein-containing Complex Leukocyte Activation Anterograde Axonal Transport Protein Kinase Inhibitor Activity Kinesin Complex Axon Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Positive Regulation Of Signal Transduction Centriolar Subdistal Appendage Mitotic Spindle Growth Cone Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Intracellular Signaling Cassette Lysosome Localization Microtubule Anchoring At Centrosome Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Cell Activation JNK Cascade	Stress Granule Disassembly Inorganic Cation Transmembrane Transporter Activity Embryonic Cranial Skeleton Morphogenesis Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Kinesin Complex Kinesin Binding Cytoskeletal Motor Activity Limb Development Organelle Disassembly Embryonic Skeletal System Morphogenesis
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