KIT and JAK3

Number of citations of the paper that reports this interaction (PubMedID 17554063)
52

Data Source:
BioGRID (enzymatic study)

		KIT	JAK3
Description		KIT proto-oncogene, receptor tyrosine kinase	Janus kinase 3
Image
GO Annotations	Cellular Component	Fibrillar Center Acrosomal Vesicle Extracellular Space Cytoplasm Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Cytoplasm Endosome Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Nucleotide Binding Protease Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Cytokine Binding SH2 Domain Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding
	Biological Process	Ovarian Follicle Development Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Mast Cell Chemotaxis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Glycosphingolipid Metabolic Process Chemotaxis Inflammatory Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Spermatid Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Germ Cell Migration Regulation Of Cell Shape Gonad Development Visual Learning Male Gonad Development Response To Radiation Positive Regulation Of Gene Expression Programmed Cell Death Cell Migration Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Lamellipodium Assembly Actin Cytoskeleton Organization Hemopoiesis B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Mast Cell Cytokine Production Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Intracellular Signal Transduction Hematopoietic Stem Cell Migration Megakaryocyte Development Fc Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAPK Cascade Pigmentation Tongue Development Leukocyte Activation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cadmium Ion Protein Autophosphorylation Developmental Pigmentation Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Regulation Of Developmental Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Melanocyte Migration Melanocyte Adhesion Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Regulation Of Bile Acid Metabolic Process Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Reproductive Process	Adaptive Immune Response Immune System Process Negative Regulation Of Dendritic Cell Cytokine Production Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Cell Differentiation B Cell Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Apoptotic Process T Cell Homeostasis Innate Immune Response Negative Regulation Of T-helper 1 Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of T Cell Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Response To Interleukin-9 Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Dasatinib-resistant KIT mutants Imatinib-resistant KIT mutants KIT mutants bind TKIs Masitinib-resistant KIT mutants Nilotinib-resistant KIT mutants Regorafenib-resistant KIT mutants Signaling by kinase domain mutants of KIT Sunitinib-resistant KIT mutants Signaling by juxtamembrane domain KIT mutants Sorafenib-resistant KIT mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by extracellular domain mutants of KIT Transcriptional and post-translational regulation of MITF-M expression and activity Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells	Interleukin-7 signaling Interleukin-7 signaling Signaling by ALK RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling Potential therapeutics for SARS
Drugs		Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Nilotinib XL820 OSI-930 Linifanib Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Ancestim Tivozanib Fostamatinib Erdafitinib Amuvatinib Pexidartinib Ripretinib Avapritinib	2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one R-348 Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Zanubrutinib
Diseases		Acute myeloid leukemia (AML) Piebaldism	T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Adult body size ( 32376654) Anorexia nervosa or obsessive-compulsive disorder ( 30087453) Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 19416921) Breastfeeding duration ( 25475840) Cadmium levels ( 26025379) HDL cholesterol levels ( 32203549) Hematocrit ( 28017375 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 28017375) High density lipoprotein cholesterol levels ( 31928498) Mean corpuscular hemoglobin ( 28017375 29403010 28453575) Mean corpuscular volume ( 28453575 28017375 20139978 29403010 19862010) Neutrophil percentage of white cells ( 32888494) Platelet count ( 29403010) Red blood cell count ( 29403010 28453575 28017375) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum VEGFR2 concentration ( 25411163) Systemic lupus erythematosus ( 29494758) Triglyceride levels ( 31928498 32203549)
Interacting Genes		92 interacting genes: ABL1 ABL2 BCAR3 BLK BLNK BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF1R CSF2RA CSF2RB DOK1 EPOR FES FGR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK HSH2D IL7R ILKAP INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ NCK1 NCK2 PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCE1 PLCG1 PLCG2 PRKCA PRKCB PTK6 PTPN11 PTPN20 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SLA2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B STYX SYK TEC TNS1 TNS2 TNS3 TXK VAV3 YES1 ZAP70	43 interacting genes: ALK APOA1 CD247 CD40 CD81 CDK1 CISH CXCR4 ERBB3 FES GTF2B IKBKG IL2RB IL2RG IL4R IL7R INPP5D IRS1 IRS2 JAK1 JAK2 KHDRBS1 KIT LCK LNX1 PIK3R1 PRMT5 PTK2B PTPN2 PTPN6 PTPRC SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT3 STAT5A STAT5B UHRF2 VIL1
Entrez ID		3815	3718
HPRD ID		01287	02547
Ensembl ID		ENSG00000157404	ENSG00000105639
Uniprot IDs		A0A0U2N547 A0A8I5KQZ6 A0A8I5KS03 A0A8I5QKL5 A0A8I5QKP7 A0A8J8Z860 P10721	P52333
PDB IDs		1PKG 1T45 1T46 2E9W 2EC8 2IUH 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4PGZ 4U0I 6GQJ 6GQK 6GQL 6GQM 6HH1 6ITT 6ITV 6KLA 6MOB 6XV9 6XVA 6XVB 7KHG 7KHJ 7KHK 7ZW8 7ZY6 8DFM 8DFP 8DFQ 8PQ9 8PQA 8PQB 8PQC 8PQD 8PQE 8PQF 8PQG	1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q 4QPS 4QT1 4RIO 4V0G 4Z16 5LWM 5LWN 5TOZ 5TTS 5TTU 5TTV 5VO6 5W86 5WFJ 6AAK 6DA4 6DB3 6DB4 6DUD 6GL9 6GLA 6GLB 6HZV 6NY4 7APF 7APG 7C3N 7Q6H 7UYV 8EXM
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Immune Response Positive Regulation Of Immune Response Regulation Of Cell Activation Cell Activation Leukocyte Activation Regulation Of Signal Transduction Immune System Process Intracellular Signal Transduction Immune Response-activating Signaling Pathway Cytosol Lymphocyte Activation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Activation Of Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Immune Effector Process Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Cytokine-mediated Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Plasma Membrane Receptor Tyrosine Kinase Binding Negative Regulation Of Immune System Process T Cell Activation Protein Phosphorylation Fc Receptor Signaling Pathway ERBB Signaling Pathway Phosphorylation	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Activation Regulation Of Cell Differentiation Positive Regulation Of Cell Activation Regulation Of Cell Development Regulation Of Developmental Process Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT T Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Activation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Lymphocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Via STAT T Cell Activation Lymphocyte Mediated Immunity Regulation Of Immune Response Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Cell-cell Adhesion Mononuclear Cell Differentiation Lymphocyte Differentiation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Differentiation Immune System Process B Cell Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Cell Development Leukocyte Mediated Immunity Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Apoptotic Process Leukocyte Differentiation
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