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KIT and YES1
Number of citations of the paper that reports this interaction (PubMedID
11071635
)
0
Data Source:
HPRD
(in vitro)
KIT
YES1
Description
KIT proto-oncogene, receptor tyrosine kinase
YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Cytoplasm
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Anchoring Junction
Molecular Function
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Transmembrane Transporter Binding
Biological Process
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Chemotaxis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Spermatid Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Gonad Development
Visual Learning
Male Gonad Development
Response To Radiation
Positive Regulation Of Gene Expression
Programmed Cell Death
Cell Migration
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Actin Cytoskeleton Organization
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Positive Regulation Of Mast Cell Cytokine Production
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Pigmentation
Tongue Development
Leukocyte Activation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Developmental Pigmentation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Regulation Of Developmental Process
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Negative Regulation Of Reproductive Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of D-glucose Transmembrane Transport
Cell Differentiation
T Cell Costimulation
Cellular Response To Platelet-derived Growth Factor Stimulus
Protein Modification Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
Transcriptional and post-translational regulation of MITF-M expression and activity
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
Co-stimulation by CD28
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
Linifanib
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Dasatinib
Fostamatinib
Diseases
Acute myeloid leukemia (AML)
Piebaldism
GWAS
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
28017375
29403010
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
28017375
29403010
28453575
)
Mean corpuscular volume (
28453575
28017375
20139978
29403010
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
31928498
32203549
)
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
29403010
30224653
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Interacting Genes
92 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DRC4
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NHERF1
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
RASA1
RPL10
SH3GLB2
SKAP2
SOCS1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
Entrez ID
3815
7525
HPRD ID
01287
01285
Ensembl ID
ENSG00000157404
ENSG00000176105
Uniprot IDs
A0A0U2N547
A0A8I5KQZ6
A0A8I5KS03
A0A8I5QKL5
A0A8I5QKP7
A0A8J8Z860
P10721
P07947
PDB IDs
1PKG
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
7KHG
7KHJ
7KHK
7ZW8
7ZY6
8DFM
8DFP
8DFQ
8PQ9
8PQA
8PQB
8PQC
8PQD
8PQE
8PQF
8PQG
2HDA
Enriched GO Terms of Interacting Partners
?
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune System Process
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cell Activation
Cell Activation
Leukocyte Activation
Regulation Of Signal Transduction
Immune System Process
Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Cytosol
Lymphocyte Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Activation Of Immune Response
Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Activation
Positive Regulation Of T Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Immune Effector Process
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Plasma Membrane
Receptor Tyrosine Kinase Binding
Negative Regulation Of Immune System Process
T Cell Activation
Protein Phosphorylation
Fc Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Receptor Complex
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signaling
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
Identical Protein Binding
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Migration
Regulation Of Apoptotic Process
Plasma Membrane
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Motility
Regulation Of Developmental Process
Cell Migration
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Regulation Of Locomotion
Positive Regulation Of Phosphate Metabolic Process
Response To Growth Factor
Positive Regulation Of Protein Modification Process
Protein Kinase Activity
Cell Motility
SH3 Domain Binding
Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Population Proliferation
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Tagcloud (Intersection)
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