KIT and SPRED2

Number of citations of the paper that reports this interaction (PMID 12646235)
15

Data Source:
HPRD (in vivo)

		KIT	SPRED2
Gene Name		v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	sprouty-related, EVH1 domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Extracellular Space Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Mast Cell Granule	Nucleoplasm Cytoplasm Plasma Membrane Transport Vesicle Membrane
	Molecular Function	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Cytokine Binding Protein Homodimerization Activity Metal Ion Binding	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Activation Of MAPK Activity Ovarian Follicle Development Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Maintenance Signal Transduction By Phosphorylation Lamellipodium Assembly Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Somatic Stem Cell Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Megakaryocyte Development Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Developmental Pigmentation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion	Inactivation Of MAPK Activity Multicellular Organismal Development Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Deacetylation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of KIT signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Adenosine-5\'-Diphosphate Nilotinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS		Bipolar disorder ( 19416921) Mean corpuscular volume ( 20139978 19862010) Red blood cell traits ( 23222517)	Celiac disease and Rheumatoid arthritis ( 21383967) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		56 interactors: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B TEC YES1	5 interactors: KIT RHOA SPG21 TOP3B ZDHHC17
Entrez ID		3815	200734
HPRD ID		01287	18100
Ensembl ID		ENSG00000157404	ENSG00000198369
Uniprot IDs		P10721	B3KPL5 Q7Z698
PDB IDs		1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F 4HVS	2JP2
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Immune Response Regulation Of Immune System Process Response To Peptide Hormone Positive Regulation Of Immune System Process Signal Transduction Cellular Response To Organonitrogen Compound Intracellular Signal Transduction Cellular Response To Organic Substance Response To Peptide Regulation Of Body Fluid Levels Response To Organic Substance Immune System Process Signaling Regulation Of Cell Activation Cell Communication Cellular Response To Hormone Stimulus Blood Coagulation Hemostasis Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Wound Healing Regulation Of Signaling Innate Immune Response Regulation Of Cell Adhesion Response To Organonitrogen Compound Regulation Of Lymphocyte Activation Response To Hormone Immune Response-regulating Signaling Pathway Cellular Response To Stimulus Leukocyte Migration Immune Response Response To Wounding Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Activation	Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Phosphatidylinositol-mediated Signaling Positive Regulation Of Intracellular Signal Transduction Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Differentiation Skeletal Muscle Satellite Cell Migration Cellular Response To Erythropoietin Mast Cell Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Bone Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apolipoprotein A-I-mediated Signaling Pathway Melanocyte Migration Cleavage Furrow Formation Positive Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Myeloid Progenitor Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Lymphoid Progenitor Cell Differentiation Positive Regulation Of Pseudopodium Assembly Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Neurogenesis Ectopic Germ Cell Programmed Cell Death Immature B Cell Differentiation Cytokine Production Involved In Immune Response Cell Division Megakaryocyte Development Response To Thyroid Hormone Ossification Involved In Bone Maturation Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Bone Maturation Regulation Of Cell Projection Organization Negative Chemotaxis Mitotic Spindle Assembly Lipoprotein Transport Germ Cell Migration
Tagcloud ?		advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated	3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3
Tagcloud (Difference) ?		advantage blast blasts cd34 clonal clusters colonies continuously csf cytokines granulocyte immunomagnetic leukemic macrophage microspheres ng physiologic progenitor purified rg rgm ril rm rscf saturating scf subdivided supported undifferentiated	3g bim bolsters btg3 cdc25a cfue cyclinb1 deployed eaf1 engages epo epor erythroblast erythroblasts gas5 interrogate lyl1 maturing pim1 pim3 presently proerythroblast serpina sf13c socs2 sophisticated tnfr trib3
Tagcloud (Intersection) ?