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KIT and FYN
Number of citations of the paper that reports this interaction (PubMedID
9799234
)
74
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
KIT
FYN
Description
KIT proto-oncogene, receptor tyrosine kinase
FYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Fibrillar Center
Acrosomal Vesicle
Extracellular Space
Cytoplasm
Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Nucleus
Cytoplasm
Mitochondrion
Endosome
Cytosol
Actin Filament
Plasma Membrane
Postsynaptic Density
Membrane
Dendrite
Perikaryon
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Cell Periphery
Perinuclear Endoplasmic Reticulum
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Nucleotide Binding
Protease Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Stem Cell Factor Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Cytokine Binding
SH2 Domain Binding
Protein Homodimerization Activity
Metal Ion Binding
Nucleotide Binding
G Protein-coupled Receptor Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Tubulin Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Enzyme Binding
Type 5 Metabotropic Glutamate Receptor Binding
T Cell Receptor Binding
CD4 Receptor Binding
CD8 Receptor Binding
Identical Protein Binding
Alpha-tubulin Binding
Phospholipase Binding
Phosphatidylinositol 3-kinase Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Metal Ion Binding
Ephrin Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Peptide Hormone Receptor Binding
Growth Factor Receptor Binding
Scaffold Protein Binding
Disordered Domain Specific Binding
Biological Process
Ovarian Follicle Development
Hematopoietic Progenitor Cell Differentiation
Myeloid Progenitor Cell Differentiation
Lymphoid Progenitor Cell Differentiation
Immature B Cell Differentiation
Mast Cell Chemotaxis
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Glycosphingolipid Metabolic Process
Chemotaxis
Inflammatory Response
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Spermatogenesis
Spermatid Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Regulation Of Cell Shape
Gonad Development
Visual Learning
Male Gonad Development
Response To Radiation
Positive Regulation Of Gene Expression
Programmed Cell Death
Cell Migration
Cytokine-mediated Signaling Pathway
Stem Cell Population Maintenance
Lamellipodium Assembly
Actin Cytoskeleton Organization
Hemopoiesis
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Melanocyte Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Positive Regulation Of Mast Cell Cytokine Production
Somatic Stem Cell Population Maintenance
Embryonic Hemopoiesis
Ectopic Germ Cell Programmed Cell Death
Intracellular Signal Transduction
Hematopoietic Stem Cell Migration
Megakaryocyte Development
Fc Receptor Signaling Pathway
Kit Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Programmed Cell Death
Mast Cell Degranulation
Positive Regulation Of MAPK Cascade
Pigmentation
Tongue Development
Leukocyte Activation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cadmium Ion
Protein Autophosphorylation
Developmental Pigmentation
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Digestive Tract Development
Stem Cell Differentiation
Epithelial Cell Proliferation
Regulation Of Developmental Process
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Mast Cell Differentiation
Mast Cell Proliferation
Positive Regulation Of Mast Cell Proliferation
Melanocyte Migration
Melanocyte Adhesion
Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction
Regulation Of Bile Acid Metabolic Process
Positive Regulation Of Colon Smooth Muscle Contraction
Positive Regulation Of Small Intestine Smooth Muscle Contraction
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Negative Regulation Of Reproductive Process
Response To Singlet Oxygen
Neuron Migration
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Immune System Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Heart Process
Calcium Ion Transport
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Glutamate Receptor Signaling Pathway
Axon Guidance
Learning
Feeding Behavior
Regulation Of Cell Shape
Response To Xenobiotic Stimulus
Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
Positive Regulation Of Neuron Projection Development
Negative Regulation Of Angiogenesis
Protein Ubiquitination
Peptidyl-tyrosine Phosphorylation
Layer Formation In Cerebral Cortex
Natural Killer Cell Activation
Cell Differentiation
Protein Catabolic Process
Forebrain Development
Neuron Projection Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Cellular Response To Platelet-derived Growth Factor Stimulus
Reelin-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Protein Catabolic Process
Response To Cocaine
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Response To Ethanol
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendrite Morphogenesis
Activated T Cell Proliferation
Modulation Of Chemical Synaptic Transmission
T Cell Receptor Signaling Pathway
Leukocyte Migration
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Hydrogen Peroxide
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Protein Targeting To Membrane
Dendritic Spine Maintenance
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Glutamate Receptor Signaling Pathway
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Dendritic Spine Maintenance
Response To Amyloid-beta
Cellular Response To Amyloid-beta
Cellular Response To L-glutamate
Cellular Response To Glycine
Positive Regulation Of Protein Localization To Membrane
Regulation Of Calcium Ion Import Across Plasma Membrane
Regulation Of Neuron Migration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Dasatinib-resistant KIT mutants
Imatinib-resistant KIT mutants
KIT mutants bind TKIs
Masitinib-resistant KIT mutants
Nilotinib-resistant KIT mutants
Regorafenib-resistant KIT mutants
Signaling by kinase domain mutants of KIT
Sunitinib-resistant KIT mutants
Signaling by juxtamembrane domain KIT mutants
Sorafenib-resistant KIT mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by extracellular domain mutants of KIT
Transcriptional and post-translational regulation of MITF-M expression and activity
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Alveolar Cells
GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
DAP12 signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Nephrin family interactions
NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth
Co-stimulation by CD28
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF1 (M-CSF) in myeloid cells
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Sorafenib
Imatinib
Dasatinib
Sunitinib
Phosphonotyrosine
Nilotinib
XL820
OSI-930
Linifanib
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Ancestim
Tivozanib
Fostamatinib
Erdafitinib
Amuvatinib
Pexidartinib
Ripretinib
Avapritinib
Dasatinib
Triglyme
Fostamatinib
Zotiraciclib
Diseases
Acute myeloid leukemia (AML)
Piebaldism
GWAS
Adult body size (
32376654
)
Anorexia nervosa or obsessive-compulsive disorder (
30087453
)
Apolipoprotein A1 levels (
32203549
)
Bipolar disorder (
19416921
)
Breastfeeding duration (
25475840
)
Cadmium levels (
26025379
)
HDL cholesterol levels (
32203549
)
Hematocrit (
28017375
29403010
)
Hemoglobin (
29403010
)
Hemoglobin levels (
28017375
)
High density lipoprotein cholesterol levels (
31928498
)
Mean corpuscular hemoglobin (
28017375
29403010
28453575
)
Mean corpuscular volume (
28453575
28017375
20139978
29403010
19862010
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
29403010
)
Red blood cell count (
29403010
28453575
28017375
)
Red blood cell traits (
23222517
)
Schizophrenia (
26198764
)
Serum VEGFR2 concentration (
25411163
)
Systemic lupus erythematosus (
29494758
)
Triglyceride levels (
31928498
32203549
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Anger (
24489884
)
Autoimmune thyroid disease (
32581359
)
Bipolar disorder (
31043756
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Height (
31562340
)
Inflammatory bowel disease (
28067908
23128233
)
Intraocular pressure (
29617998
)
Macular thickness (
30535121
)
NASH resolution in nonalcoholic steatohepatitis (
31832568
)
Parkinson's disease (
32201043
32310270
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Schizophrenia (
28991256
30285260
)
Systolic blood pressure (
30578418
)
Ulcerative colitis (
28067908
)
Interacting Genes
92 interacting genes:
ABL1
ABL2
BCAR3
BLK
BLNK
BTK
CBL
CBLB
CD81
CD9
CISH
CLTC
CRK
CRKL
CSF1R
CSF2RA
CSF2RB
DOK1
EPOR
FES
FGR
FYN
GRAP
GRAP2
GRB10
GRB2
GRB7
HCK
HSH2D
IL7R
ILKAP
INPP5D
JAK2
JAK3
KITLG
LCK
LYN
MATK
MPDZ
NCK1
NCK2
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCE1
PLCG1
PLCG2
PRKCA
PRKCB
PTK6
PTPN11
PTPN20
PTPN6
PTPRO
PTPRU
RASA1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SLA2
SOCS1
SOCS2
SOCS3
SOCS5
SOCS6
SPRED1
SPRED2
SRC
STAP1
STAT1
STAT5A
STAT5B
STYX
SYK
TEC
TNS1
TNS2
TNS3
TXK
VAV3
YES1
ZAP70
199 interacting genes:
ACP1
ADAM15
ADD2
ARHGAP32
ARHGAP33
ATXN1
BAG4
BCAR1
BCL3
BTK
C7orf25
C8orf33
CASP3
CASP8
CAV1
CBL
CBLB
CBLC
CD19
CD2
CD226
CD247
CD2AP
CD36
CD44
CD48
CD5
CD55
CD79A
CD79B
CDH1
CDK1
CDK5
CLTC
CMA1
CNN1
CNN3
CNTN1
CNTNAP1
CRK
CSF1R
CSF2RB
CSK
CTLA4
CTNNB1
CTNND2
DAG1
DLG4
DLGAP4
DOK1
DOK3
DOK4
DTX3
EFS
ENO1
EPHA3
EPHA4
EPHA8
EPHB3
EVL
FAM90A1
FAS
FASLG
FCER2
FCGR2A
FLOT1
FLOT2
FLT1
FNBP4
FYB1
GAB3
GP6
GRAP
GRB10
GRB2
GRIN1
GRIN2A
GRIN2B
GRSF1
HNRNPK
HRAS
HSP90AA1
HTR6
IGHA1
IL1B
IL2RB
IL7R
IRS1
ITCH
ITGB4
ITK
ITPR1
JAK2
JUP
KDM1A
KDR
KHDRBS1
KIT
LAT
LCK
LCP2
MAG
MAP2
MAPT
MCAM
MED28
MEOX2
MS4A1
NCAM1
NEDD4
NEDD9
NMT1
NOS1AP
NPHS1
NR3C1
NTRK2
PAG1
PAK2
PDE4D
PDGFRB
PECAM1
PIK3R1
PIK3R2
PIK3R3
PLAUR
PLCG1
PLCG2
PLD2
PRKCD
PRKCE
PRKCH
PRKCQ
PRKCZ
PRMT6
PRMT8
PRRG4
PTK2
PTK2B
PTPN11
PTPN5
PTPRA
PTPRC
PTPRE
PTPRF
PTPRZ1
PXN
RACK1
RAF1
RPL10
RPS6KA3
RPS6KB2
SDC3
SH2B2
SH2D1A
SH3BP2
SHC1
SIT1
SKAP1
SKAP2
SLAMF1
SNCA
SOCS1
SOS1
SPHK1
SPHK2
SPN
STAT1
STAT3
SUV39H1
SYK
TAMALIN
TCAP
THY1
TNF
TNK2
TNNT1
TOM1L1
TRAF6
TRAT1
TRIM55
TRIM63
TRPC6
TRPV4
TUBA1B
TUBA3C
TUBA4A
TXK
TYK2
TYRO3
UHRF2
UNC119
VAV1
VAV2
WAS
WASF1
WASF2
WBP11
YTHDC1
ZAP70
Entrez ID
3815
2534
HPRD ID
01287
00655
Ensembl ID
ENSG00000157404
ENSG00000010810
Uniprot IDs
A0A0U2N547
A0A8I5KQZ6
A0A8I5KS03
A0A8I5QKL5
A0A8I5QKP7
A0A8J8Z860
P10721
P06241
PDB IDs
1PKG
1T45
1T46
2E9W
2EC8
2IUH
2VIF
3G0E
3G0F
4HVS
4K94
4K9E
4PGZ
4U0I
6GQJ
6GQK
6GQL
6GQM
6HH1
6ITT
6ITV
6KLA
6MOB
6XV9
6XVA
6XVB
7KHG
7KHJ
7KHK
7ZW8
7ZY6
8DFM
8DFP
8DFQ
8PQ9
8PQA
8PQB
8PQC
8PQD
8PQE
8PQF
8PQG
1A0N
1AOT
1AOU
1AVZ
1AZG
1EFN
1FYN
1G83
1M27
1NYF
1NYG
1SHF
1ZBJ
2DQ7
2MQI
2MRJ
2MRK
3H0F
3H0H
3H0I
3UA6
3UA7
4D8D
4EIK
4U17
4U1P
4ZNX
5ZAU
6EDF
6IPY
6IPZ
7A2J
7A2K
7A2L
7A2M
7A2N
7A2O
7A2P
7A2Q
7A2R
7A2S
7A2T
7A2U
7A2V
7A2W
7A2X
7A2Y
7A2Z
7UD6
8KDX
Enriched GO Terms of Interacting Partners
?
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Immune System Process
Signal Transduction
Immune Response-activating Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Adhesion
Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Positive Regulation Of Immune Response
Regulation Of Cell Activation
Cell Activation
Leukocyte Activation
Regulation Of Signal Transduction
Immune System Process
Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Cytosol
Lymphocyte Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Immune Response-regulating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Activation Of Immune Response
Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Activation
Positive Regulation Of T Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Immune Effector Process
Regulation Of T Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
B Cell Receptor Signaling Pathway
Plasma Membrane
Receptor Tyrosine Kinase Binding
Negative Regulation Of Immune System Process
T Cell Activation
Protein Phosphorylation
Fc Receptor Signaling Pathway
ERBB Signaling Pathway
Phosphorylation
Cell Surface Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Activation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Regulation Of Multicellular Organismal Process
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Leukocyte Activation
Enzyme-linked Receptor Protein Signaling Pathway
Cell Activation
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Phosphotyrosine Residue Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Lymphocyte Activation
Positive Regulation Of Cell Adhesion
Membrane Raft
Regulation Of Cell Activation
T Cell Receptor Signaling Pathway
Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Protein Tyrosine Kinase Activity
Immune Response
Regulation Of Cell-cell Adhesion
Regulation Of Programmed Cell Death
Intracellular Signaling Cassette
Fc Receptor Signaling Pathway
Regulation Of Apoptotic Process
SH2 Domain Binding
Adaptive Immune Response
Cell Adhesion
Protein Kinase Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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