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TRIM74 and UBE2U
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
TRIM74
UBE2U
Gene Name
tripartite motif containing 74
ubiquitin-conjugating enzyme E2U (putative)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Nuclear Chromatin
Cytoplasm
HULC Complex
Molecular Function
Zinc Ion Binding
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Polyubiquitination
DNA Repair
Histone Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
BRCA1
LRSAM1
MGRN1
RBX1
REL
RNF32
TSG101
UBE2U
USP15
USP2
USP32
66 interactors:
ANAPC11
BARD1
BFAR
CADPS2
CGRRF1
DTX1
DZIP3
GOLGA2
KAT6A
MDM2
MIB1
MIB2
MID2
MKRN3
MUL1
PCGF1
PCGF2
PCGF6
PJA1
PML
RBCK1
RNF10
RNF11
RNF113A
RNF113B
RNF114
RNF125
RNF139
RNF14
RNF144B
RNF150
RNF166
RNF17
RNF170
RNF181
RNF2
RNF25
RNF26
RNF41
RNF5
RNFT1
SYVN1
TRAIP
TRIM15
TRIM2
TRIM23
TRIM24
TRIM27
TRIM28
TRIM3
TRIM32
TRIM34
TRIM35
TRIM37
TRIM38
TRIM46
TRIM47
TRIM5
TRIM54
TRIM63
TRIM65
TRIM68
TRIM74
VPS11
VPS41
ZSWIM2
Entrez ID
378108
148581
HPRD ID
15567
14599
Ensembl ID
ENSG00000155428
ENSG00000177414
Uniprot IDs
Q86UV6
Q5VVX9
PDB IDs
1YRV
Enriched GO Terms of Interacting Partners
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Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Protein Polyubiquitination
Catabolic Process
Protein Ubiquitination
Cellular Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Viral Budding
Protein Deubiquitination
Proteolysis
Protein Modification By Small Protein Removal
Protein Metabolic Process
Virion Assembly
Regulation Of Proteasomal Protein Catabolic Process
Protein Monoubiquitination
Protein Autoubiquitination
Cellular Metabolic Process
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Ubiquitin-dependent Endocytosis
Regulation Of Protein Catabolic Process
Membrane Budding
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Signal Transduction
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Histone H3-K9 Acetylation
Histone H2B Conserved C-terminal Lysine Deubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Viral Process
Negative Regulation Of Gene Expression
DNA Repair
Negative Regulation Of Biosynthetic Process
Cellular Response To Indole-3-methanol
Regulation Of Proteolysis
Negative Regulation Of Centriole Replication
Regulation Of Extracellular Vesicular Exosome Assembly
Viral Life Cycle
Dosage Compensation By Inactivation Of X Chromosome
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Negative Regulation Of Viral Release From Host Cell
Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Protein Polyubiquitination
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Viral Process
Protein Catabolic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Innate Immune Response
Proteasomal Protein Catabolic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Macromolecule Catabolic Process
Regulation Of Protein Stability
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Regulation Of Gene Expression
Histone H2A Ubiquitination
Histone H2A-K119 Monoubiquitination
Immune Response
Regulation Of Intracellular Transport
Cellular Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Defense Response
Interferon-gamma-mediated Signaling Pathway
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Negative Regulation Of Cellular Metabolic Process
Regulation Of Viral Entry Into Host Cell
Response To Stress
Negative Regulation Of Viral Transcription
Regulation Of Apoptotic Process
Regulation Of RNA Metabolic Process
Cellular Response To Interferon-gamma
Protein Destabilization
Regulation Of Signal Transduction
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