TRIM74 and LRSAM1

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRIM74	LRSAM1
Description		tripartite motif containing 74	leucine rich repeat and sterile alpha motif containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Innate Immune Response	Protein Polyubiquitination Autophagy Protein Transport Protein Ubiquitination Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Mean corpuscular volume ( 32888494)
Interacting Genes		11 interacting genes: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32	46 interacting genes: ATXN1 ATXN7 CCDC6 DMAP1 FAM178B FXR1 GABARAPL2 GPR108 GRIK5 GSK3A HUNK KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSC1 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2I UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11 XAF1 ZMAT4
Entrez ID		378108	90678
HPRD ID		15567	14325
Ensembl ID		ENSG00000155428	ENSG00000148356
Uniprot IDs		Q86UV6	A0A6Q8PGW1 Q6UWE0
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Ubiquitin-modified Histone Reader Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Cysteine-type Deubiquitinase Activity Ubiquitin Protein Ligase Binding Protein Deubiquitination Proteolysis Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Removal Regulation Of Signal Transduction By P53 Class Mediator Cysteine-type Peptidase Activity Regulation Of Signal Transduction Viral Budding Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Type I Interferon Production Regulation Of Organelle Assembly Protein Monoubiquitination Endosome To Lysosome Transport Regulation Of Intracellular Signal Transduction Autophagy Cysteine-type Endopeptidase Activity Positive Regulation Of TORC1 Signaling Cytoplasm Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Antifungal Innate Immune Response Positive Regulation Of TOR Signaling Nuclear Body Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of TORC1 Signaling Positive Regulation Of Protein Autoubiquitination VCB Complex Ubiquitin Ligase Complex BRCA1-B Complex	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Macromolecule Catabolic Process Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Transferase Activity Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Negative Regulation Of TOR Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Ubiquitination Protein Monoubiquitination Macromolecule Metabolic Process TORC1 Signaling Positive Regulation Of Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Nucleus Regulation Of TOR Signaling ATP Binding TOR Signaling Positive Regulation Of Protein Targeting To Mitochondrion Nucleotide Binding Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of TORC1 Signaling Regulation Of Protein Ubiquitination Regulation Of Protein Targeting To Mitochondrion Proteasomal Protein Catabolic Process ESCRT I Complex Endosome To Lysosome Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Catabolic Process Cytosol Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Excitatory Postsynaptic Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nutrient Levels Regulation Of Macromolecule Metabolic Process
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