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TRIM74 and LRSAM1
Number of citations of the paper that reports this interaction (PMID
22493164
)
2
Data Source:
BioGRID
(two hybrid)
TRIM74
LRSAM1
Gene Name
tripartite motif containing 74
leucine rich repeat and sterile alpha motif containing 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Extracellular Region
Cytoplasm
Membrane
Molecular Function
Zinc Ion Binding
Ubiquitin-protein Transferase Activity
Hormone Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Protein Polyubiquitination
Protein Catabolic Process
Negative Regulation Of Endocytosis
Viral Budding
Protein Autoubiquitination
Ubiquitin-dependent Endocytosis
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
11 interactors:
BRCA1
LRSAM1
MGRN1
RBX1
REL
RNF32
TSG101
UBE2U
USP15
USP2
USP32
36 interactors:
ATXN1
ATXN7
FAM178B
GABARAPL2
GPR108
GRIK5
GSK3A
KLC1
MDM4
MGAT4B
MKRN3
MUTYH
MYL2
NINL
PHF23
RNF111
RXRG
TERF1
TNFRSF10C
TRIM17
TRIM74
TSG101
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2H
UBE2J1
UBE2K
UBE2N
UBE2W
UEVLD
USP2
USP21
VPS11
Entrez ID
378108
90678
HPRD ID
15567
14325
Ensembl ID
ENSG00000155428
ENSG00000148356
Uniprot IDs
Q86UV6
Q6UWE0
PDB IDs
Enriched GO Terms of Interacting Partners
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Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Protein Polyubiquitination
Catabolic Process
Protein Ubiquitination
Cellular Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Viral Budding
Protein Deubiquitination
Proteolysis
Protein Modification By Small Protein Removal
Protein Metabolic Process
Virion Assembly
Regulation Of Proteasomal Protein Catabolic Process
Protein Monoubiquitination
Protein Autoubiquitination
Cellular Metabolic Process
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Ubiquitin-dependent Endocytosis
Regulation Of Protein Catabolic Process
Membrane Budding
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Signal Transduction
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Positive Regulation Of Histone H3-K9 Acetylation
Histone H2B Conserved C-terminal Lysine Deubiquitination
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Signaling
Regulation Of Protein Metabolic Process
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Viral Process
Negative Regulation Of Gene Expression
DNA Repair
Negative Regulation Of Biosynthetic Process
Cellular Response To Indole-3-methanol
Regulation Of Proteolysis
Negative Regulation Of Centriole Replication
Regulation Of Extracellular Vesicular Exosome Assembly
Viral Life Cycle
Dosage Compensation By Inactivation Of X Chromosome
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Modification Process
Catabolic Process
Regulation Of Protein Catabolic Process
Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Protein Metabolic Process
Negative Regulation Of Protein Catabolic Process
Negative Regulation Of Proteasomal Protein Catabolic Process
Protein Metabolic Process
Negative Regulation Of Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Toll-like Receptor Signaling Pathway
Mitotic Spindle Assembly Checkpoint
Cellular Response To Oxygen Levels
Spindle Assembly Checkpoint
Cellular Response To Stress
Mitotic Spindle Checkpoint
Regulation Of Proteolysis
Protein Monoubiquitination
Negative Regulation Of Chromosome Segregation
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Mitotic Sister Chromatid Separation
Negative Regulation Of Mitotic Nuclear Division
Spindle Checkpoint
Activation Of Innate Immune Response
Cellular Metabolic Process
Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
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