TRIM74 and RNF32

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRIM74	RNF32
Description		tripartite motif containing 74	ring finger protein 32
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Endosome Cytosol Aggresome Nuclear Body
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Innate Immune Response
Pathways
Drugs
Diseases
GWAS			Glomerular filtration rate (creatinine) ( 26831199)
Interacting Genes		11 interacting genes: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32	42 interacting genes: A2M APOE APP BLMH CDC37 CDK5 CEP55 CYP2C8 CYP2C9 ECSIT ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 FIBP GCDH HOXC4 IFIT3 IFIT5 LONP1 LOXL4 LZTS2 MAST1 MKRN3 MNAT1 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN1 PSEN2 RAB3A RAB3D RAD23A RPP30 STAMBPL1 TRIM23 TRIM74 UBE2K
Entrez ID		378108	140545
HPRD ID		15567	11517
Ensembl ID		ENSG00000155428	ENSG00000105982
Uniprot IDs		Q86UV6	G5E940 Q9H0A6
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Ubiquitin-modified Histone Reader Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Cysteine-type Deubiquitinase Activity Ubiquitin Protein Ligase Binding Protein Deubiquitination Proteolysis Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Removal Regulation Of Signal Transduction By P53 Class Mediator Cysteine-type Peptidase Activity Regulation Of Signal Transduction Viral Budding Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Type I Interferon Production Regulation Of Organelle Assembly Protein Monoubiquitination Endosome To Lysosome Transport Regulation Of Intracellular Signal Transduction Autophagy Cysteine-type Endopeptidase Activity Positive Regulation Of TORC1 Signaling Cytoplasm Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Antifungal Innate Immune Response Positive Regulation Of TOR Signaling Nuclear Body Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of TORC1 Signaling Positive Regulation Of Protein Autoubiquitination VCB Complex Ubiquitin Ligase Complex BRCA1-B Complex	Positive Regulation Of Amyloid Fibril Formation Lipoprotein Particle Catabolic Process Acetylcholine Receptor Activator Activity Cellular Response To Amyloid-beta Regulation Of Amyloid Fibril Formation Response To Amyloid-beta Amyloid Precursor Protein Metabolic Process Astrocyte Activation Involved In Immune Response Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Gamma-secretase Complex Regulation Of Synaptic Plasticity Macromolecule Catabolic Process Oxidative Demethylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Amyloid-beta Formation Notch Receptor Processing Regulation Of Proteolysis Regulation Of Vesicle-mediated Transport Demethylation Synaptic Vesicle Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Negative Regulation Of Long-term Synaptic Potentiation Growth Cone Regulation Of Immune Response Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Epoxygenase P450 Pathway Synaptic Membrane Mitotic Cytokinesis Low-density Lipoprotein Particle Removal Of Superoxide Radicals Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Regulation Of Innate Immune Response Regulation Of Hemostasis Amyloid Precursor Protein Catabolic Process Maintenance Of Location In Cell Heparan Sulfate Proteoglycan Binding Negative Regulation Of Platelet Activation Astrocyte Activation
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