TRIM74

Description		tripartite motif containing 74
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Innate Immune Response
Pathways
Drugs
Diseases
GWAS
Interacting Genes		11 interacting genes: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32
Entrez ID		378108
HPRD ID		15567
Ensembl ID		ENSG00000155428
Uniprot IDs		Q86UV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Ubiquitin-modified Histone Reader Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Cysteine-type Deubiquitinase Activity Ubiquitin Protein Ligase Binding Protein Deubiquitination Proteolysis Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Removal Regulation Of Signal Transduction By P53 Class Mediator Cysteine-type Peptidase Activity Regulation Of Signal Transduction Viral Budding Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Type I Interferon Production Regulation Of Organelle Assembly Protein Monoubiquitination Endosome To Lysosome Transport Regulation Of Intracellular Signal Transduction Autophagy Cysteine-type Endopeptidase Activity Positive Regulation Of TORC1 Signaling Cytoplasm Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Antifungal Innate Immune Response Positive Regulation Of TOR Signaling Nuclear Body Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of TORC1 Signaling Positive Regulation Of Protein Autoubiquitination VCB Complex Ubiquitin Ligase Complex BRCA1-B Complex
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