TRIM74 and MGRN1

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		TRIM74	MGRN1
Description		tripartite motif containing 74	mahogunin ring finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Innate Immune Response	Protein Polyubiquitination Protein Monoubiquitination Smoothened Signaling Pathway Heart Development Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			A body shape index ( 34021172) Appendicular lean mass ( 33097823) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Milk allergy (maternal genetic effects) ( 29489655) Triglyceride levels ( 32154731)
Interacting Genes		11 interacting genes: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32	13 interacting genes: AMFR TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W
Entrez ID		378108	23295
HPRD ID		15567	07397
Ensembl ID		ENSG00000155428	ENSG00000102858
Uniprot IDs		Q86UV6	O60291
PDB IDs
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Polyubiquitination Protein Modification Process Protein Metabolic Process Ubiquitin-modified Histone Reader Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Cysteine-type Deubiquitinase Activity Ubiquitin Protein Ligase Binding Protein Deubiquitination Proteolysis Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Removal Regulation Of Signal Transduction By P53 Class Mediator Cysteine-type Peptidase Activity Regulation Of Signal Transduction Viral Budding Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Type I Interferon Production Regulation Of Organelle Assembly Protein Monoubiquitination Endosome To Lysosome Transport Regulation Of Intracellular Signal Transduction Autophagy Cysteine-type Endopeptidase Activity Positive Regulation Of TORC1 Signaling Cytoplasm Protein Autoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Signal Transduction Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Positive Regulation Of Ubiquitin-dependent Endocytosis Negative Regulation Of Antifungal Innate Immune Response Positive Regulation Of TOR Signaling Nuclear Body Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of TORC1 Signaling Positive Regulation Of Protein Autoubiquitination VCB Complex Ubiquitin Ligase Complex BRCA1-B Complex	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Modification Process Transferase Activity Catabolic Process ATP Binding Protein K6-linked Ubiquitination Protein Metabolic Process Protein K11-linked Ubiquitination Nucleotide Binding Protein Monoubiquitination Protein Autoubiquitination Protein K27-linked Ubiquitination Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein K29-linked Ubiquitination ERAD Pathway Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Establishment Of Protein Localization Regulation Of Protein Targeting To Mitochondrion Cellular Response To Stress Response To Endoplasmic Reticulum Stress SUMO Conjugating Enzyme Activity Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Establishment Of Protein Localization TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex RING-like Zinc Finger Domain Binding Regulation Of TORC1 Signaling
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