PTPN2 and ITGA1

Number of citations of the paper that reports this interaction (PMID 15592458)
42

Data Source:
HPRD (in vitro, two hybrid)

		PTPN2	ITGA1
Gene Name		protein tyrosine phosphatase, non-receptor type 2	integrin, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding	Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Prolactin Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Negative Regulation Of Cell Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation
Pathways			Platelet Adhesion to exposed collagen CHL1 interactions Axon guidance Laminin interactions Semaphorin interactions Other semaphorin interactions Smooth Muscle Contraction L1CAM interactions Integrin cell surface interactions
Drugs
Diseases
GWAS		C-reactive protein ( 21300955) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Crohn's disease ( 18587394 17554261 17554300 21102463) Esophageal cancer (squamous cell) ( 22960999) Rheumatoid arthritis ( 22446963) Type 1 diabetes ( 19430480 17554260 18978792) Type 1 diabetes autoantibodies ( 21829393)	Alzheimer's disease biomarkers ( 23419831) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Response to platinum-based agents ( 22020760)
Protein-Protein Interactions		18 interactors: CDK1 CDK2 CDK5 EGFR FKBP4 GHR INSR ITGA1 JAK1 JAK3 KPNB1 PDGFRB SHC1 SRC STAT1 STAT3 STAT5A STAT5B	10 interactors: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
Entrez ID		5771	3672
HPRD ID		06768	01892
Ensembl ID		ENSG00000175354
Uniprot IDs		A8K3N4 K7ENG3 K7EQG9 P17706 Q59F91	P56199
PDB IDs		1L8K	1PT6 1QC5 1QCY 2L8S 4A0Q
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Response To Hormone Response To Growth Hormone Peptidyl-amino Acid Modification Response To Peptide Intracellular Signal Transduction Cellular Response To Organic Substance JAK-STAT Cascade Positive Regulation Of MAP Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of DNA Metabolic Process Cell Communication Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Phosphorylation Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Biosynthetic Process Signal Transduction Protein Autophosphorylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Response To Cytokine Activation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity	Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization System Development Multicellular Organismal Development Anatomical Structure Development Cell Adhesion Developmental Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Organ Development Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Tissue Development Collagen Catabolic Process Cellular Component Assembly Organ Morphogenesis Axon Guidance Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Prolactin Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-2-mediated Signaling Pathway Collagen Metabolic Process Cell Morphogenesis Blood Vessel Morphogenesis Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Endocytosis B Cell Differentiation Negative Regulation Of Inflammatory Response Blood Vessel Development Nervous System Development Lipid Tube Assembly Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Cell-cell Junction Assembly Axonogenesis Vasculature Development Bone Morphogenesis Axon Development Formation Of Primary Germ Layer
Tagcloud ?		6alpha acidic astrocytes astroglial atf6alpha ciliary cntf deactivation dissect fibrillary gfap glia glial infarct lif master mcao neurotrophic peri phenylbutyrate protein78 scar stressors tc thapsigargin transducer tunicamycin unfolded
Tagcloud (Difference) ?		6alpha acidic astrocytes astroglial atf6alpha ciliary cntf deactivation dissect fibrillary gfap glia glial infarct lif master mcao neurotrophic peri phenylbutyrate protein78 scar stressors tc thapsigargin transducer tunicamycin unfolded
Tagcloud (Intersection) ?