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PTPN2 and GHR
Number of citations of the paper that reports this interaction (PubMedID
12907755
)
0
Data Source:
HPRD
(in vitro)
PTPN2
GHR
Description
protein tyrosine phosphatase non-receptor type 2
growth hormone receptor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Membrane
Endosome Lumen
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
Hydrolase Activity
Protein Kinase Binding
Syntaxin Binding
Receptor Tyrosine Kinase Binding
STAT Family Protein Binding
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Lipid Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cytokine Binding
Protein Tyrosine Kinase Activator Activity
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Protein Tyrosine Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Peptidyl-tyrosine Dephosphorylation
Insulin Receptor Recycling
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Chemotaxis
Regulation Of Type II Interferon-mediated Signaling Pathway
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Endocytosis
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Response To Gravity
Response To Hormone
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Receptor Internalization
Response To Food
Regulation Of Response To Nutrient Levels
Response To Estradiol
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Response To Cytokine
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cycloheximide
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Glucocorticoid
Cartilage Development Involved In Endochondral Bone Morphogenesis
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Response To Growth Hormone
Response To Interleukin-1
Pathways
Negative regulation of MET activity
Interleukin-37 signaling
PKR-mediated signaling
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Lonapegsomatropin
Diseases
Type I diabetes mellitus
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Alopecia areata (
25608926
)
Autoimmune thyroid disease (
32581359
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index (
25673413
)
C-reactive protein levels (
30388399
21300955
)
Celiac disease (
20190752
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
17554261
28067908
25489960
21102463
17554300
18587394
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Esophageal cancer (squamous cell) (
22960999
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
28067908
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lead levels in blood (
25820613
)
Lymphocyte count (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Psoriasis (
28537254
)
Red blood cell count (
32888494
)
Rheumatoid arthritis (
30423114
24390342
23143596
22446963
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Selective IgA deficiency (
27723758
)
Type 1 diabetes (
25751624
21829393
19430480
18978792
17554260
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
25429064
28552196
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Interacting Genes
26 interacting genes:
CDK1
CDK2
CDK5
CRYAA
EGFR
FAM220A
FKBP4
GHR
GJB1
HMGB1
INSR
ITGA1
JAK1
JAK3
KPNB1
OCLN
PDGFRB
SHC1
SRC
STAT1
STAT3
STAT5A
STAT5B
STX17
TMEM132D
UBC
44 interacting genes:
AP2A1
BTRC
CISH
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
5771
2690
HPRD ID
06768
02971
Ensembl ID
ENSG00000175354
ENSG00000112964
Uniprot IDs
A8K3N4
K7EQG9
P17706
Q59F91
A0A087X0H5
A0A087X162
P10912
PDB IDs
1L8K
6ZZ4
7F5N
7F5O
7UAD
8U0H
8UH6
9C54
9C55
9C56
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
6I5J
6I5N
Enriched GO Terms of Interacting Partners
?
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-9-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Phosphatase Binding
Interleukin-7-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Kinase Activity
Phosphorylation
Positive Regulation Of Cell Population Proliferation
Kinase Activity
Protein Tyrosine Kinase Activity
Protein Phosphorylation
Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Growth
CCR5 Chemokine Receptor Binding
Response To Cytokine
Regulation Of Apoptotic Process
Response To Peptide
Cytokine-mediated Signaling Pathway
Regulation Of Programmed Cell Death
Taurine Metabolic Process
Regulation Of Growth
Regulation Of Macromolecule Biosynthetic Process
Response To Peptide Hormone
Positive Regulation Of MAPK Cascade
Regulation Of Developmental Growth
Positive Regulation Of Myeloid Cell Differentiation
Nuclear Glucocorticoid Receptor Binding
Regulation Of Erythrocyte Differentiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cell Migration
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Tyrosine Kinase Activator Activity
Shc-EGFR Complex
Interleukin-6-mediated Signaling Pathway
Response To Interleukin-15
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Carbohydrate Catabolic Process
Regulation Of Multicellular Organism Growth
Regulation Of Macromolecule Metabolic Process
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Modification Process
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway Via STAT
Cytosol
Protein Dephosphorylation
Growth Hormone Receptor Binding
Protein Tyrosine Phosphatase Activity
Peptidyl-tyrosine Dephosphorylation
Signal Transduction
Protein Metabolic Process
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Macromolecule Metabolic Process
Cul5-RING Ubiquitin Ligase Complex
Dephosphorylation
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Cellular Response To Insulin Stimulus
Protein Ubiquitination
Insulin Receptor Binding
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Modification By Small Protein Conjugation
Regulation Of Signaling
Regulation Of Cell Communication
Post-translational Protein Modification
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Regulation Of Cell Adhesion
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cytoplasm
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