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PTPN2 and OCLN
Number of citations of the paper that reports this interaction (PubMedID
26090670
)
37
Data Source:
BioGRID
(enzymatic study)
PTPN2
OCLN
Description
protein tyrosine phosphatase non-receptor type 2
occludin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Membrane
Endosome Lumen
Lysosomal Membrane
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Membrane
Apical Plasma Membrane
Apicolateral Plasma Membrane
Cell Junction
Endocytic Vesicle
Cell Leading Edge
Cytoplasmic Vesicle
Protein-containing Complex
Tight Junction
Anchoring Junction
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Integrin Binding
Protein Binding
Hydrolase Activity
Protein Kinase Binding
Syntaxin Binding
Receptor Tyrosine Kinase Binding
STAT Family Protein Binding
Protein Binding
Protein Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
B Cell Differentiation
T Cell Differentiation
Erythrocyte Differentiation
Peptidyl-tyrosine Dephosphorylation
Insulin Receptor Recycling
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Chemotaxis
Regulation Of Type II Interferon-mediated Signaling Pathway
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Lamellipodium Assembly
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Epithelial Cell Migration
Regulation Of D-glucose Transmembrane Transport
Positive Regulation Of Microtubule Polymerization
Maintenance Of Blood-brain Barrier
Cell-cell Junction Organization
Positive Regulation Of D-glucose Import
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Positive Regulation Of Wound Healing
Tight Junction Organization
Protein Localization To Cell Leading Edge
Positive Regulation Of Blood-brain Barrier Permeability
Pathways
Negative regulation of MET activity
Interleukin-37 signaling
PKR-mediated signaling
Apoptotic cleavage of cell adhesion proteins
RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
Type I diabetes mellitus
Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS
Alopecia areata (
25608926
)
Autoimmune thyroid disease (
32581359
)
Autoimmune traits (pleiotropy) (
30572963
)
Body mass index (
25673413
)
C-reactive protein levels (
30388399
21300955
)
Celiac disease (
20190752
22057235
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
17554261
28067908
25489960
21102463
17554300
18587394
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Esophageal cancer (squamous cell) (
22960999
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
28067908
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Lead levels in blood (
25820613
)
Lymphocyte count (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Psoriasis (
28537254
)
Red blood cell count (
32888494
)
Rheumatoid arthritis (
30423114
24390342
23143596
22446963
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Selective IgA deficiency (
27723758
)
Type 1 diabetes (
25751624
21829393
19430480
18978792
17554260
)
Hand grip strength (Mahalanobis distance) (
32235003
)
Interleukin-18 levels (
27989323
)
Interacting Genes
26 interacting genes:
CDK1
CDK2
CDK5
CRYAA
EGFR
FAM220A
FKBP4
GHR
GJB1
HMGB1
INSR
ITGA1
JAK1
JAK3
KPNB1
OCLN
PDGFRB
SHC1
SRC
STAT1
STAT3
STAT5A
STAT5B
STX17
TMEM132D
UBC
12 interacting genes:
CLEC7A
CSNK1A1
CSNK2A1
FATE1
GPX8
OGT
PTPN2
SNW1
SYNE4
TNFAIP3
ULK1
USP40
Entrez ID
5771
100506658
HPRD ID
06768
Ensembl ID
ENSG00000175354
ENSG00000197822
Uniprot IDs
A8K3N4
K7EQG9
P17706
Q59F91
A0A0G2JMZ8
A8K3T2
Q16625
PDB IDs
1L8K
6ZZ4
7F5N
7F5O
7UAD
8U0H
8UH6
9C54
9C55
9C56
1WPA
1XAW
3G7C
Enriched GO Terms of Interacting Partners
?
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-9-mediated Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Phosphatase Binding
Interleukin-7-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Kinase Activity
Phosphorylation
Positive Regulation Of Cell Population Proliferation
Kinase Activity
Protein Tyrosine Kinase Activity
Protein Phosphorylation
Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Growth
CCR5 Chemokine Receptor Binding
Response To Cytokine
Regulation Of Apoptotic Process
Response To Peptide
Cytokine-mediated Signaling Pathway
Regulation Of Programmed Cell Death
Taurine Metabolic Process
Regulation Of Growth
Regulation Of Macromolecule Biosynthetic Process
Response To Peptide Hormone
Positive Regulation Of MAPK Cascade
Regulation Of Developmental Growth
Positive Regulation Of Myeloid Cell Differentiation
Nuclear Glucocorticoid Receptor Binding
Regulation Of Erythrocyte Differentiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Population Proliferation
Cell Migration
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Tyrosine Kinase Activator Activity
Shc-EGFR Complex
Interleukin-6-mediated Signaling Pathway
Response To Interleukin-15
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Carbohydrate Catabolic Process
Regulation Of Multicellular Organism Growth
Regulation Of Macromolecule Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Protein Catabolic Process
Positive Regulation Of Signaling
Negative Regulation Of Protein-containing Complex Assembly
Sin3-type Complex
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of Protein-containing Complex Assembly
Macroautophagy
Protein Modification Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Autophagy
Cellular Response To Nutrient
Positive Regulation Of Catabolic Process
Positive Regulation Of Protein Catabolic Process
Cellular Response To Nutrient Levels
Regulation Of Signaling
Negative Regulation Of Translational Initiation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Gluconeogenesis
Negative Regulation Of Positive Thymic T Cell Selection
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Regulation Of Cytokine-mediated Signaling Pathway
Tolerance Induction To Lipopolysaccharide
Negative Regulation Of Toll-like Receptor 5 Signaling Pathway
Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Mitophagy
Protein N-acetylglucosaminyltransferase Complex
Negative Regulation Of Non-canonical Inflammasome Complex Assembly
Detection Of Yeast
Detection Of Molecule Of Fungal Origin
TORC1 Signaling
Proteolysis
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Establishment Of Protein Localization To Vacuole
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Interleukin-2 Production
Positive Regulation Of TORC1 Signaling
Autophagy
Organelle Assembly
Regulation Of Insulin Receptor Signaling Pathway
Autophagy Of Mitochondrion
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