PTPN2 and FAM220A

Number of citations of the paper that reports this interaction (PubMedID 26026268)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PTPN2	FAM220A
Description		protein tyrosine phosphatase non-receptor type 2	family with sequence similarity 220 member A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Endosome Lumen	Acrosomal Vesicle Nucleus Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding STAT Family Protein Binding	Protein Binding STAT Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Insulin Receptor Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Negative regulation of MET activity Interleukin-37 signaling PKR-mediated signaling
Drugs
Diseases		Type I diabetes mellitus
GWAS		Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 25673413) C-reactive protein levels ( 30388399 21300955) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 28067908 25489960 21102463 17554300 18587394) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels in blood ( 25820613) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Psoriasis ( 28537254) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 24390342 23143596 22446963) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758) Type 1 diabetes ( 25751624 21829393 19430480 18978792 17554260)	Body mass index ( 26426971) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		26 interacting genes: CDK1 CDK2 CDK5 CRYAA EGFR FAM220A FKBP4 GHR GJB1 HMGB1 INSR ITGA1 JAK1 JAK3 KPNB1 OCLN PDGFRB SHC1 SRC STAT1 STAT3 STAT5A STAT5B STX17 TMEM132D UBC	3 interacting genes: NEK6 PTPN2 TEKT4
Entrez ID		5771	84792
HPRD ID		06768	14427
Ensembl ID		ENSG00000175354	ENSG00000178397
Uniprot IDs		A8K3N4 K7EQG9 P17706 Q59F91	Q7Z4H9
PDB IDs		1L8K 6ZZ4 7F5N 7F5O 7UAD 8U0H 8UH6 9C54 9C55 9C56
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-9-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Phosphatase Binding Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Phosphorylation Positive Regulation Of Cell Population Proliferation Kinase Activity Protein Tyrosine Kinase Activity Protein Phosphorylation Interleukin-4-mediated Signaling Pathway Positive Regulation Of Growth CCR5 Chemokine Receptor Binding Response To Cytokine Regulation Of Apoptotic Process Response To Peptide Cytokine-mediated Signaling Pathway Regulation Of Programmed Cell Death Taurine Metabolic Process Regulation Of Growth Regulation Of Macromolecule Biosynthetic Process Response To Peptide Hormone Positive Regulation Of MAPK Cascade Regulation Of Developmental Growth Positive Regulation Of Myeloid Cell Differentiation Nuclear Glucocorticoid Receptor Binding Regulation Of Erythrocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Tyrosine Kinase Activator Activity Shc-EGFR Complex Interleukin-6-mediated Signaling Pathway Response To Interleukin-15 Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Multicellular Organism Growth Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Interleukin-2-mediated Signaling Pathway Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Insulin Receptor Recycling Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Type II Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Differentiation Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of T Cell Differentiation In Thymus Protein Kinase Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon STAT Family Protein Binding Mitotic Nuclear Membrane Disassembly Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Nuclear Membrane Disassembly Regulation Of PERK-mediated Unfolded Protein Response Membrane Disassembly Negative Regulation Of Peptidyl-tyrosine Phosphorylation Endosome Lumen Negative Regulation Of Lipid Storage Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Differentiation In Thymus Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Axonemal A Tubule Inner Sheath Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Receptor Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Organelle Assembly Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Axonemal Microtubule Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Microtubule-based Process
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