PTPN2 and STAT5B

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
HPRD (in vivo, in vitro)

		PTPN2	STAT5B
Gene Name		protein tyrosine phosphatase, non-receptor type 2	signal transducer and activator of transcription 5B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage Cytokine-mediated Signaling Pathway B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Prolactin Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Allantoin Metabolic Process Luteinization Response To Hypoxia Natural Killer Cell Differentiation Liver Development Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Acute-phase Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus
Pathways			Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs			Dasatinib
Diseases
GWAS		C-reactive protein ( 21300955) Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) Crohn's disease ( 18587394 17554261 17554300 21102463) Esophageal cancer (squamous cell) ( 22960999) Rheumatoid arthritis ( 22446963) Type 1 diabetes ( 19430480 17554260 18978792) Type 1 diabetes autoantibodies ( 21829393)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		18 interactors: CDK1 CDK2 CDK5 EGFR FKBP4 GHR INSR ITGA1 JAK1 JAK3 KPNB1 PDGFRB SHC1 SRC STAT1 STAT3 STAT5A STAT5B	49 interactors: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		5771	6777
HPRD ID		06768	05037
Ensembl ID		ENSG00000175354	ENSG00000173757
Uniprot IDs		A8K3N4 K7ENG3 K7EQG9 P17706 Q59F91	P51692
PDB IDs		1L8K
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Response To Hormone Response To Growth Hormone Peptidyl-amino Acid Modification Response To Peptide Intracellular Signal Transduction Cellular Response To Organic Substance JAK-STAT Cascade Positive Regulation Of MAP Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of DNA Metabolic Process Cell Communication Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity Phosphorylation Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Biosynthetic Process Signal Transduction Protein Autophosphorylation Positive Regulation Of Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Response To Cytokine Activation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity	Cellular Response To Organic Substance Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Hormone Regulation Of MAPK Cascade Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Response To Cytokine Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Phosphorylation Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Cellular Response To Growth Hormone Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Signaling Regulation Of Phosphorus Metabolic Process Signal Transduction JAK-STAT Cascade Positive Regulation Of MAPK Cascade Defense Response Cell Communication Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Immune System Process Cellular Response To Cytokine Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Response To Peptide Hormone Positive Regulation Of Transferase Activity Innate Immune Response
Tagcloud ?		6alpha acidic astrocytes astroglial atf6alpha ciliary cntf deactivation dissect fibrillary gfap glia glial infarct lif master mcao neurotrophic peri phenylbutyrate protein78 scar stressors tc thapsigargin transducer tunicamycin unfolded	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Difference) ?		6alpha acidic astrocytes astroglial atf6alpha ciliary cntf deactivation dissect fibrillary gfap glia glial infarct lif master mcao neurotrophic peri phenylbutyrate protein78 scar stressors tc thapsigargin transducer tunicamycin unfolded	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Intersection) ?