Wiki-Pi
About
Search
People
Updates
Search
IL2RB and IL15RA
Number of citations of the paper that reports this interaction (PubMedID
7641685
)
38
Data Source:
HPRD
(in vitro, in vivo)
IL2RB
IL15RA
Description
interleukin 2 receptor subunit beta
interleukin 15 receptor subunit alpha
Image
GO Annotations
Cellular Component
Endosome
Cytosol
Plasma Membrane
Interleukin-2 Receptor Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Golgi Membrane
Extracellular Region
Nucleus
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Nuclear Membrane
Molecular Function
Cytokine Receptor Activity
Interleukin-2 Receptor Activity
Protein Binding
Coreceptor Activity
Interleukin-2 Binding
Interleukin-15 Receptor Activity
Cytokine Receptor Activity
Protein Binding
Protein Kinase Binding
Interleukin-15 Receptor Activity
Biological Process
Signal Transduction
Immunoglobulin Mediated Immune Response
Cytokine-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of Phagocytosis
Protein-containing Complex Assembly
Natural Killer Cell Differentiation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Neuron Projection Development
Response To Nutrient Levels
Positive Regulation Of Natural Killer Cell Differentiation
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Phagocytosis
Pathways
RAF/MAP kinase cascade
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling
Interleukin-15 signaling
Interleukin-15 signaling
Drugs
Denileukin diftitox
Aldesleukin
Basiliximab
Daclizumab
Diseases
GWAS
Asthma (
20860503
32296059
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
L-selectin levels (
25576479
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
27863252
)
Rheumatoid arthritis (
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Tuberculosis (
24057671
)
Type 1 diabetes (
21829393
)
Alopecia areata (
25608926
)
Asthma (
31619474
31959851
)
Asthma (bronchodilator response) (
23508266
)
Atopic dermatitis (
26482879
)
Blood protein levels (
30072576
)
Diisocyanate-induced asthma (
25918132
)
Inflammatory bowel disease (
23128233
)
Medication use (thyroid preparations) (
31015401
)
Neuroblastoma (pediatric) (
32599975
)
Soluble interleukin-2 receptor subunit alpha (
26293465
)
Interacting Genes
29 interacting genes:
CISH
EIF3B
FYN
GRB2
HGS
IL15
IL15RA
IL2
IL2RA
IL2RG
JAK1
JAK3
LCK
LYN
MTDH
PIK3R1
PTPN6
RACK1
RAF1
SHB
SHC1
SOCS1
SOCS3
STAT1
STAT3
STAT5A
STAT5B
SYK
TRIP13
12 interacting genes:
AXL
BCL10
CASK
CDK2
CDK4
IL15
IL2RB
IL2RG
PIAS4
RCVRN
SYK
TRAF2
Entrez ID
3560
3601
HPRD ID
00896
03045
Ensembl ID
ENSG00000100385
ENSG00000134470
Uniprot IDs
P14784
A0A0A0MS77
G8CVM3
Q13261
PDB IDs
2B5I
2ERJ
3QAZ
4GS7
5M5E
6E8K
7S2S
2ERS
2Z3Q
2Z3R
4GS7
Enriched GO Terms of Interacting Partners
?
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Hemopoiesis
Lymphocyte Activation
Regulation Of Multicellular Organismal Development
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of T Cell Activation
Leukocyte Activation
Regulation Of Developmental Process
Positive Regulation Of Leukocyte Cell-cell Adhesion
Interleukin-2-mediated Signaling Pathway
Regulation Of Lymphocyte Differentiation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Lymphocyte Activation
Cell Activation
Positive Regulation Of Lymphocyte Differentiation
Interleukin-9-mediated Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Activation
Positive Regulation Of Developmental Process
Regulation Of Cell Adhesion
Cell Differentiation
Mononuclear Cell Differentiation
Regulation Of Cell Development
Growth Hormone Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of T Cell Differentiation
Positive Regulation Of Leukocyte Differentiation
Leukocyte Differentiation
Regulation Of Multicellular Organismal Process
T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Signal Transduction
Lymphocyte Differentiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Lymphocyte Proliferation
Cellular Developmental Process
Mononuclear Cell Proliferation
Positive Regulation Of T Cell Differentiation
Interleukin-7-mediated Signaling Pathway
Regulation Of Cell Differentiation
Activated T Cell Proliferation
Positive Regulation Of Endocytosis
Interleukin-15-mediated Signaling Pathway
Regulation Of Production Of Molecular Mediator Of Immune Response
Regulation Of Cytokine Production Involved In Immune Response
Regulation Of Endocytosis
Regulation Of Vesicle-mediated Transport
Interleukin-15 Receptor Activity
Interleukin-2 Binding
Interleukin-2 Receptor Activity
Regulation Of Phagocytosis
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of Lymphocyte Differentiation
Signal Transduction
Immune Response
Positive Regulation Of Cell Activation
Positive Regulation Of Mast Cell Cytokine Production
Regulation Of Cytokine-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Leukocyte Differentiation
Positive Regulation Of Transport
Lymphocyte Activation
Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Differentiation
Cellular Response To Oxygen-containing Compound
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Kinase Activity
Regulation Of Lymphocyte Activation
Positive Regulation Of Phagocytosis
Lymphocyte Differentiation
Positive Regulation Of Natural Killer Cell Differentiation
Leukocyte Activation
Positive Regulation Of T Cell Activation
Positive Regulation Of Immune System Process
Regulation Of Transport
Interleukin-2-mediated Signaling Pathway
Positive Regulation Of Immune Effector Process
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Leukocyte Cell-cell Adhesion
Kinase Activity
Regulation Of Natural Killer Cell Differentiation
T Cell Activation
Regulation Of Cell Activation
Positive Regulation Of Cellular Component Organization
Cell Activation
Transferase Activity
Cellular Response To Nitric Oxide
Mononuclear Cell Differentiation
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of B Cell Differentiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?