IL2RB and CISH

Number of citations of the paper that reports this interaction (PMID 10514520)
14

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		IL2RB	CISH
Gene Name		interleukin 2 receptor, beta	cytokine inducible SH2-containing protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Cellular_component Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-2 Binding	Molecular_function Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Protein Complex Assembly Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Cytokine Signaling in Immune system Growth hormone receptor signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Asthma ( 20860503) Rheumatoid arthritis ( 21653640) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		27 interactors: CISH EIF3B FYN GNB2L1 GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN PIK3R1 PTPN6 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK	18 interactors: CSF2RB CSF3R EGFR EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		3560	1154
HPRD ID		00896	03897
Ensembl ID		ENSG00000100385	ENSG00000114737
Uniprot IDs		P14784	Q9NSE2
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide JAK-STAT Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Organic Substance Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Defense Response Response To Hormone Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Cell Activation Cell Activation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Intracellular Signal Transduction Regulation Of Cell Adhesion Innate Immune Response Regulation Of Signaling Signaling Regulation Of Lymphocyte Differentiation Regulation Of JAK-STAT Cascade Cell Communication Response To Cytokine Response To Interleukin-2 Regulation Of Protein Metabolic Process Platelet Activation	Cellular Response To Organic Substance Response To Organic Substance Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Cytokine Stimulus Cellular Response To Stimulus Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Histone H3-T6 Phosphorylation Erythropoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Activation Of JAK2 Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Growth Factor Chemotaxis Negative Regulation Of Cell Death Cellular Response To Erythropoietin Regulation Of MAPK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability
Tagcloud (Difference) ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability
Tagcloud (Intersection) ?