IL2RB and IL2RA

Number of citations of the paper that reports this interaction (PMID 11886175)
2

Data Source:
HPRD (in vivo)

		IL2RB	IL2RA
Gene Name		interleukin 2 receptor, beta	interleukin 2 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-2 Binding	Interleukin-2 Receptor Activity Drug Binding Interleukin-2 Binding
	Biological Process	Protein Complex Assembly Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Inflammatory Response To Antigenic Stimulus Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Asthma ( 20860503) Rheumatoid arthritis ( 21653640) Type 1 diabetes autoantibodies ( 21829393)	Alopecia areata ( 20596022) Asthma (bronchodilator response) ( 23508266) Crohn's disease ( 21102463) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 19525953 19525955 17660530 21833088) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 22293688 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-Protein Interactions		27 interactors: CISH EIF3B FYN GNB2L1 GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN PIK3R1 PTPN6 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK	8 interactors: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B
Entrez ID		3560	3559
HPRD ID		00896	00986
Ensembl ID		ENSG00000100385	ENSG00000134460
Uniprot IDs		P14784	P01589 Q5W005
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide JAK-STAT Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Organic Substance Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Defense Response Response To Hormone Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Cell Activation Cell Activation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Intracellular Signal Transduction Regulation Of Cell Adhesion Innate Immune Response Regulation Of Signaling Signaling Regulation Of Lymphocyte Differentiation Regulation Of JAK-STAT Cascade Cell Communication Response To Cytokine Response To Interleukin-2 Regulation Of Protein Metabolic Process Platelet Activation	Negative Regulation Of Cell Death Cellular Response To Cytokine Stimulus Response To Cytokine T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Acute Inflammatory Response Regulation Of Cell Death Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Interleukin-2 Negative Regulation Of Programmed Cell Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cytokine Biosynthetic Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Response To Bacterium Response To Ethanol Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Viral Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Signal Transduction Response To Copper Ion Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Interleukin-2 Biosynthetic Process Growth Hormone Receptor Signaling Pathway Defense Response Cellular Response To Growth Hormone Stimulus Regulation Of Cell Adhesion Cellular Response To Interleukin-6 Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation
Tagcloud ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?