IL2RB and EIF3B

Number of citations of the paper that reports this interaction (PMID 7693677)
3

Data Source:
HPRD (in vivo)

		IL2RB	EIF3B
Gene Name		interleukin 2 receptor, beta	eukaryotic translation initiation factor 3, subunit B
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-2 Binding	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Protein Complex Scaffold
	Biological Process	Protein Complex Assembly Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Asthma ( 20860503) Rheumatoid arthritis ( 21653640) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		27 interactors: CISH EIF3B FYN GNB2L1 GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN PIK3R1 PTPN6 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK	8 interactors: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 IL2RB UPF1
Entrez ID		3560	8662
HPRD ID		00896	06795
Ensembl ID		ENSG00000100385	ENSG00000106263
Uniprot IDs		P14784	P55884
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7	2KRB 2NLW
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide JAK-STAT Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Organic Substance Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Defense Response Response To Hormone Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Cell Activation Cell Activation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Intracellular Signal Transduction Regulation Of Cell Adhesion Innate Immune Response Regulation Of Signaling Signaling Regulation Of Lymphocyte Differentiation Regulation Of JAK-STAT Cascade Cell Communication Response To Cytokine Response To Interleukin-2 Regulation Of Protein Metabolic Process Platelet Activation	Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Translation Dosage Compensation By Inactivation Of X Chromosome Ribonucleoprotein Complex Biogenesis Dosage Compensation Cytoplasmic Translation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Histone H3-K9 Acetylation Nuclear Export Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Interleukin-2-mediated Signaling Pathway Response To Cytokine RNA Catabolic Process Formation Of Cytoplasmic Translation Initiation Complex Cellular Response To Indole-3-methanol Regulation Of Metabolic Process Negative Regulation Of Centriole Replication Regulation Of Gene Expression, Epigenetic Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Mature Ribosome Assembly Regulation Of Histone H3-K9 Acetylation Protein Metabolic Process Ribosomal Subunit Export From Nucleus Histone MRNA Catabolic Process Nucleocytoplasmic Transport Cytoplasmic Translational Initiation Nuclear Transport
Tagcloud ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www
Tagcloud (Difference) ?		autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www
Tagcloud (Intersection) ?		attenuation