IL2RB and IL15

Number of citations of the paper that reports this interaction (PMID 8026467)
161

Data Source:
HPRD (in vivo)

		IL2RB	IL15
Gene Name		interleukin 2 receptor, beta	interleukin 15
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Endosome Golgi Apparatus Integral Component Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-2 Binding	Cytokine Activity Cytokine Receptor Binding Protein Binding
	Biological Process	Protein Complex Assembly Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Natural Killer Cell Differentiation NK T Cell Proliferation Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Aging Positive Regulation Of Cell Proliferation Skeletal Muscle Atrophy Hyaluronan Metabolic Process Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Immune Response Cellular Response To Vitamin D
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Asthma ( 20860503) Rheumatoid arthritis ( 21653640) Type 1 diabetes autoantibodies ( 21829393)	Response to treatment for acute lymphoblastic leukemia ( 19176441)
Protein-Protein Interactions		27 interactors: CISH EIF3B FYN GNB2L1 GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN PIK3R1 PTPN6 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK	7 interactors: APP IL15RA IL2RB IL2RG STAT5B TRAF3 ZNRD1
Entrez ID		3560	3600
HPRD ID		00896	02776
Ensembl ID		ENSG00000100385	ENSG00000164136
Uniprot IDs		P14784	P40933 Q6FGX7
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7	2XQB 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide JAK-STAT Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Organic Substance Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Defense Response Response To Hormone Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Cell Activation Cell Activation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Intracellular Signal Transduction Regulation Of Cell Adhesion Innate Immune Response Regulation Of Signaling Signaling Regulation Of Lymphocyte Differentiation Regulation Of JAK-STAT Cascade Cell Communication Response To Cytokine Response To Interleukin-2 Regulation Of Protein Metabolic Process Platelet Activation	Response To Interleukin-2 Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Interleukin-2-mediated Signaling Pathway Response To Cytokine Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Response To Interleukin-4 Response To Organic Substance Regulation Of Multicellular Organism Growth Positive Regulation Of Mitotic Cell Cycle Interleukin-7-mediated Signaling Pathway Synaptic Growth At Neuromuscular Junction Signal Transduction Collateral Sprouting In Absence Of Injury Signaling Cell Communication Creatinine Metabolic Process Development Of Secondary Male Sexual Characteristics Positive Regulation Of Innate Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Isoleucine Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Allantoin Metabolic Process Positive Regulation Of Natural Killer Cell Proliferation Immune System Process Taurine Metabolic Process Axon Choice Point Recognition Regulation Of Natural Killer Cell Proliferation Regulation Of Innate Immune Response Prolactin Signaling Pathway Response To Interleukin-15 Steroid Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Cellular Response To Stimulus Negative Regulation Of Erythrocyte Differentiation Valine Metabolic Process Neuron Remodeling Creatine Metabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Gamma-delta T Cell Activation Succinate Metabolic Process Development Of Secondary Female Sexual Characteristics Regulation Of Developmental Growth Toll Signaling Pathway Positive Regulation Of Natural Killer Cell Differentiation Interleukin-4-mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics
Tagcloud ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby
Tagcloud (Difference) ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	125a 7e 99b arthritis clusters conversion depletion exacerbated immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting tnfaip3 upregulates upregulating upregulation whereby
Tagcloud (Intersection) ?		il15