IL2RB and PTPN6

Number of citations of the paper that reports this interaction (PMID 9520455)
33

Data Source:
HPRD (in vitro)

		IL2RB	PTPN6
Gene Name		interleukin 2 receptor, beta	protein tyrosine phosphatase, non-receptor type 6
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Alpha-beta T Cell Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Interleukin-2 Receptor Activity Interleukin-2 Binding	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding
	Biological Process	Protein Complex Assembly Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation Apoptotic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Costimulation by the CD28 family Signaling by SCF-KIT Interferon gamma signaling Regulation of KIT signaling Interleukin receptor SHC signaling Interferon alpha/beta signaling Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Platelet homeostasis Platelet sensitization by LDL Interleukin receptor SHC signaling PD-1 signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Asthma ( 20860503) Rheumatoid arthritis ( 21653640) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		27 interactors: CISH EIF3B FYN GNB2L1 GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN PIK3R1 PTPN6 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK	98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		3560	5777
HPRD ID		00896	01475
Ensembl ID		ENSG00000100385	ENSG00000111679
Uniprot IDs		P14784	P29350 Q53XS4
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide JAK-STAT Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Organic Substance Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Defense Response Response To Hormone Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Cell Activation Cell Activation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Intracellular Signal Transduction Regulation Of Cell Adhesion Innate Immune Response Regulation Of Signaling Signaling Regulation Of Lymphocyte Differentiation Regulation Of JAK-STAT Cascade Cell Communication Response To Cytokine Response To Interleukin-2 Regulation Of Protein Metabolic Process Platelet Activation	Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune System Process Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Immune Response Cellular Response To Stimulus Regulation Of Cell Activation Cell Activation Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Immune Response-regulating Signaling Pathway Defense Response Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Lymphocyte Activation Innate Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Cell Migration Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Blood Coagulation Hemostasis Cell Motility Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Intracellular Signal Transduction Leukocyte Activation Leukocyte Differentiation Leukocyte Migration Fc Receptor Signaling Pathway Regulation Of Signaling Response To Cytokine Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress
Tagcloud ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike	a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike
Tagcloud (Difference) ?		attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc	a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction
Tagcloud (Intersection) ?		unlike