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IL2RB and PTPN6
Number of citations of the paper that reports this interaction (PubMedID
9520455
)
30
Data Source:
HPRD
(in vitro)
IL2RB
PTPN6
Description
interleukin 2 receptor subunit beta
protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations
Cellular Component
Endosome
Cytosol
Plasma Membrane
Interleukin-2 Receptor Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
Cytokine Receptor Activity
Interleukin-2 Receptor Activity
Protein Binding
Coreceptor Activity
Interleukin-2 Binding
Interleukin-15 Receptor Activity
Phosphotyrosine Residue Binding
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Biological Process
Signal Transduction
Immunoglobulin Mediated Immune Response
Cytokine-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of Phagocytosis
Protein-containing Complex Assembly
MAPK Cascade
Mitotic Cell Cycle
Pattern Recognition Receptor Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Neutrophil Activation Involved In Immune Response
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Mast Cell Activation Involved In Immune Response
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
T Cell Proliferation
T Cell Activation
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Negative Regulation Of MAPK Cascade
Regulation Of B Cell Differentiation
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Negative Regulation Of B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Inflammatory Response To Wounding
Negative Regulation Of Inflammatory Response To Wounding
CD27 Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neutrophil Activation
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
RAF/MAP kinase cascade
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Interleukin receptor SHC signaling
GPVI-mediated activation cascade
Regulation of KIT signaling
Signaling by ALK
PECAM1 interactions
Co-inhibition by PD-1
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA/IFNB signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Nuclear events stimulated by ALK signaling in cancer
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Co-inhibition by BTLA
Drugs
Denileukin diftitox
Aldesleukin
Basiliximab
Daclizumab
Tiludronic acid
Diseases
GWAS
Asthma (
20860503
32296059
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
L-selectin levels (
25576479
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
27863252
)
Rheumatoid arthritis (
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Tuberculosis (
24057671
)
Type 1 diabetes (
21829393
)
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Interacting Genes
29 interacting genes:
CISH
EIF3B
FYN
GRB2
HGS
IL15
IL15RA
IL2
IL2RA
IL2RG
JAK1
JAK3
LCK
LYN
MTDH
PIK3R1
PTPN6
RACK1
RAF1
SHB
SHC1
SOCS1
SOCS3
STAT1
STAT3
STAT5A
STAT5B
SYK
TRIP13
118 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CNKSR1
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
H2BC3
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SNCA
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF3
TRAF6
TREML1
TYK2
VAV1
ZAP70
Entrez ID
3560
5777
HPRD ID
00896
01475
Ensembl ID
ENSG00000100385
ENSG00000111679
Uniprot IDs
P14784
P29350
Q53XS4
PDB IDs
2B5I
2ERJ
3QAZ
4GS7
5M5E
6E8K
7S2S
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
6SM5
8YHI
Enriched GO Terms of Interacting Partners
?
Cytokine-mediated Signaling Pathway
Cell Surface Receptor Signaling Pathway
Regulation Of Hemopoiesis
Lymphocyte Activation
Regulation Of Multicellular Organismal Development
Interleukin-15-mediated Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Positive Regulation Of T Cell Activation
Leukocyte Activation
Regulation Of Developmental Process
Positive Regulation Of Leukocyte Cell-cell Adhesion
Interleukin-2-mediated Signaling Pathway
Regulation Of Lymphocyte Differentiation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway Via STAT
Regulation Of Lymphocyte Activation
Cell Activation
Positive Regulation Of Lymphocyte Differentiation
Interleukin-9-mediated Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Activation
Positive Regulation Of Developmental Process
Regulation Of Cell Adhesion
Cell Differentiation
Mononuclear Cell Differentiation
Regulation Of Cell Development
Growth Hormone Receptor Signaling Pathway
Phosphotyrosine Residue Binding
Regulation Of T Cell Differentiation
Positive Regulation Of Leukocyte Differentiation
Leukocyte Differentiation
Regulation Of Multicellular Organismal Process
T Cell Activation
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Signal Transduction
Lymphocyte Differentiation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Lymphocyte Proliferation
Cellular Developmental Process
Mononuclear Cell Proliferation
Positive Regulation Of T Cell Differentiation
Interleukin-7-mediated Signaling Pathway
Regulation Of Cell Differentiation
Activated T Cell Proliferation
Cell Surface Receptor Signaling Pathway
Signal Transduction
Plasma Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Tyrosine Kinase Activity
Regulation Of Immune Response
Regulation Of Immune System Process
Enzyme-linked Receptor Protein Signaling Pathway
Immune System Process
Cytokine-mediated Signaling Pathway
Regulation Of Cell Activation
Immune Response-regulating Signaling Pathway
Leukocyte Activation
Cell Activation
Regulation Of MAPK Cascade
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Lymphocyte Activation
Membrane
Lymphocyte Activation
Receptor Complex
Positive Regulation Of MAPK Cascade
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of T Cell Activation
Regulation Of Intracellular Signal Transduction
Immune Response
Positive Regulation Of Intracellular Signal Transduction
Adaptive Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Adhesion
Regulation Of Cell-cell Adhesion
Protein Phosphatase Binding
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune Response
Regulation Of Multicellular Organismal Process
Protein Phosphorylation
Regulation Of Leukocyte Proliferation
External Side Of Plasma Membrane
Fc Receptor Signaling Pathway
Kinase Activity
Immune Response-activating Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Cell Population Proliferation
B Cell Activation
Mononuclear Cell Differentiation
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