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H2AFX and NGFR
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
H2AFX
NGFR
Gene Name
H2A histone family, member X
nerve growth factor receptor
Image
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Extracellular Region
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Neuronal Postsynaptic Density
Molecular Function
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Signal Transducer Activity
Receptor Activity
Transmembrane Signaling Receptor Activity
Death Receptor Activity
Protein Binding
Rab GTPase Binding
Ubiquitin Protein Ligase Binding
Nerve Growth Factor Binding
Biological Process
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Intracellular Protein Transport
Axon Guidance
Central Nervous System Development
Detection Of Temperature Stimulus
Nerve Development
Hair Follicle Morphogenesis
Membrane Protein Intracellular Domain Proteolysis
Circadian Regulation Of Gene Expression
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Odontogenesis Of Dentin-containing Tooth
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cell Cycle
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Regulation Of Axonogenesis
Negative Regulation Of Axonogenesis
Positive Regulation Of Axonogenesis
Negative Regulation Of Hair Follicle Development
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Regulated proteolysis of p75NTR
Signalling by NGF
NF-kB is activated and signals survival
p75NTR recruits signalling complexes
p75NTR regulates axonogenesis
p75NTR negatively regulates cell cycle via SC1
Cell death signalling via NRAGE, NRIF and NADE
Axonal growth stimulation
Ceramide signalling
p75 NTR receptor-mediated signalling
Axonal growth inhibition (RHOA activation)
NRIF signals cell death from the nucleus
NRAGE signals death through JNK
p75NTR signals via NF-kB
NFG and proNGF binds to p75NTR
NADE modulates death signalling
Drugs
Diseases
GWAS
Immune reponse to smallpox (secreted IL-2) (
22610502
)
Prostate cancer (
23535732
)
Protein-Protein Interactions
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
45 interactors:
ANXA7
BEX1
CAV1
CD80
CDKN1A
FSCN1
GRB2
H2AFX
IL2
KIDINS220
LINGO1
MAG
MAGED1
MAGEH1
MAPK1
MAPK3
NDN
NDNL2
NFKBIB
NGF
NGFRAP1
NTF4
NTRK1
NTRK2
NTRK3
PRKACB
PTPN13
RCC1
RIPK2
RPN2
RTN4R
SHC1
SMN1
SORT1
STMN2
TK1
TRA2B
TRADD
TRAF2
TRAF4
TRAF6
TRIM37
TTR
UFD1L
ZNF274
Entrez ID
3014
4804
HPRD ID
03465
01197
Ensembl ID
ENSG00000188486
ENSG00000064300
Uniprot IDs
P16104
P08138
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
3EWV
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Neurotrophin Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Enzyme Linked Receptor Protein Signaling Pathway
Response To Organic Substance
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Phosphorylation
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of MAPK Cascade
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Positive Regulation Of Transferase Activity
Positive Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Regulation Of Protein Kinase Activity
Positive Regulation Of Signal Transduction
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Protein Metabolic Process
Regulation Of Intracellular Signal Transduction
Apoptotic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Catalytic Activity
Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Neuron Projection Development
TRIF-dependent Toll-like Receptor Signaling Pathway
Response To Stimulus
Developmental Process
Regulation Of MAP Kinase Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud
?
acidophilia
astrocyte
axotomized
chat
choline
cholinergic
cresyl
depressed
die
elicit
fate
ff
fimbria
fornix
immunoreactive
itfs
jun
jund
krox
lose
medial
microglial
mystery
parvalbumin
septal
septohippocampal
transection
transferase
violet
Tagcloud (Difference)
?
acidophilia
astrocyte
axotomized
chat
choline
cholinergic
cresyl
depressed
die
elicit
fate
ff
fimbria
fornix
immunoreactive
itfs
jun
jund
krox
lose
medial
microglial
mystery
parvalbumin
septal
septohippocampal
transection
transferase
violet
Tagcloud (Intersection)
?