NGFR and MAGED1

Number of citations of the paper that reports this interaction (PubMedID 10985348)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NGFR	MAGED1
Description		nerve growth factor receptor	MAGE family member D1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse	Chromatin Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Transcription Coactivator Activity Protein Binding Identical Protein Binding
	Biological Process	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	NRAGE signals death through JNK Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Bell's palsy ( 33602968)
Interacting Genes		50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	128 interacting genes: AGRN AKAP9 ARHGEF16 ARID5A ARNT2 BAG3 BAG4 BARD1 BHLHE40 BIRC8 BRCA2 C1orf94 CA8 CAPN7 CCDC120 CCDC33 CDC23 CERCAM CFAP206 CHERP DAB1 DAZAP2 DDX6 DLX4 DLX5 DMRT2 EIF3J EIF4E2 EP300 ERCC3 FAM83A FOXD2 FOXH1 FOXI1 FXR1 FXR2 GATA5 GLRA1 GLYCTK GPANK1 GPR135 GRAP2 HEMK1 HGS HIVEP1 HNRNPH1 HNRNPLL HOXC9 HSF2BP HUNK KPNA2 KPNA6 KRTAP19-5 KRTAP6-1 KRTAP6-3 LARP4B LENG8 LONRF1 MAPK1IP1L MAPK3 MDFI MEOX2 MGAT5B MKRN3 MPC1 MSX2 NAF1 NGFR NOTCH1 NOTO NPAS4 NUMBL PHF1 PITX1 PJA1 PJA2 PLK1 PNMA5 POM121 PRKAB2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMF1 RAMAC RBFOX1 RBFOX2 RBM23 RBPMS RBPMS2 RFX1 RHOXF2 RNF6 RNF8 ROR2 RUSC1 RXFP4 SIM2 SIRT7 SMAP2 SMN1 SMN2 SNRPC SOX10 SOX5 TBX6 TFG TIAL1 TLX3 TRAF4 TRIM28 TSGA10IP TTC23 TTC32 TUBA4A UNC5A VASP VENTX XIAP YTHDF1 ZFYVE26 ZIC1 ZNF488 ZNF688
Entrez ID		4804	9500
HPRD ID		01197	02202
Ensembl ID		ENSG00000064300	ENSG00000179222
Uniprot IDs		P08138	Q9Y5V3
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation	Regulation Of RNA Metabolic Process Cytoplasmic Stress Granule Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process System Development Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleus Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding Nervous System Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Pattern Specification Process Embryonic Morphogenesis MRNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Negative Regulation Of RNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Nuclear Androgen Receptor Binding RNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Protein Import Into Nucleus Regulation Of Nucleocytoplasmic Transport Viral Penetration Into Host Nucleus Regulation Of RNA Splicing Transcription Regulator Complex
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