NGFR and BEX1

Number of citations of the paper that reports this interaction (PMID 16498402)
21

Data Source:
HPRD (in vivo)

		NGFR	BEX1
Gene Name		nerve growth factor receptor	brain expressed, X-linked 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding	RNA Polymerase II Activating Transcription Factor Binding
	Biological Process	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus	Nervous System Development Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways		Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274	5 interactors: GSK3B MDFI NGFR OMP TEX11
Entrez ID		4804	55859
HPRD ID		01197	06460
Ensembl ID		ENSG00000064300	ENSG00000133169
Uniprot IDs		P08138	Q9HBH7
PDB IDs		3EWV
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity	Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Protein Import Into Nucleus Positive Regulation Of Axonogenesis Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Binding System Development Negative Regulation Of Cell Morphogenesis Involved In Differentiation Negative Regulation Of Intracellular Transport Negative Regulation Of Neuron Projection Development Multicellular Organismal Development Negative Regulation Of Cell Projection Organization Anatomical Structure Development Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Protein Import Into Nucleus Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Protein Transport Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Negative Regulation Of Hair Follicle Development Response To Temperature Stimulus Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Neuron Differentiation Negative Regulation Of Cell Death Regulation Of Protein Localization To Nucleus Developmental Process Positive Regulation Of Apoptotic Signaling Pathway Organ Morphogenesis Regulation Of Nucleocytoplasmic Transport Hypermethylation Of CpG Island Meiotic Gene Conversion Negative Regulation Of Hair Cycle Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Neurotrophin Signaling Pathway Negative Regulation Of Signal Transduction Cellular Response To Interleukin-3 Regulation Of Binding Negative Regulation Of Signaling Organ Development Male Meiosis Chromosome Segregation Regulation Of Intracellular Protein Transport
Tagcloud ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	aza bai2 bisulfite candidate ccnd2 cdkn2a cobra colony cultures demethylating deoxycytidine ectopic ependymoma epigenetic epigenetically hypermethylation inactivation intracranial methylated microarray paediatric pharmacological restriction silenced silencing supports tumourigenesis unmasking wnt
Tagcloud (Difference) ?		acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet	aza bai2 bisulfite candidate ccnd2 cdkn2a cobra colony cultures demethylating deoxycytidine ectopic ependymoma epigenetic epigenetically hypermethylation inactivation intracranial methylated microarray paediatric pharmacological restriction silenced silencing supports tumourigenesis unmasking wnt
Tagcloud (Intersection) ?