NGFR and SHC1

Number of citations of the paper that reports this interaction (PubMedID 7541035)
0

Data Source:
HPRD (in vivo)

		NGFR	SHC1
Description		nerve growth factor receptor	SHC adaptor protein 1
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Cell-cell Junction Cell Surface Postsynaptic Density Membrane Growth Cone Neuromuscular Junction Cell Projection Dendritic Spine Perikaryon Organelle Synapse Presynapse	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Focal Adhesion Anchoring Junction Shc-EGFR Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Calmodulin Binding Coreceptor Activity Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neurotrophin Binding Nerve Growth Factor Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding
	Biological Process	Intracellular Glucose Homeostasis Hair Follicle Development Intracellular Protein Transport Apoptotic Process Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Central Nervous System Development Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Detection Of Temperature Stimulus Nerve Development Cell Differentiation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Circadian Regulation Of Gene Expression Dorsal Aorta Development Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Skin Development Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Rhythmic Process Neuron Apoptotic Process Negative Regulation Of Hair Follicle Development Extrinsic Apoptotic Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of MiRNA Transcription Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cell Population Proliferation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Regulation Of Superoxide Metabolic Process Cell-cell Adhesion
Pathways		Axonal growth inhibition (RHOA activation) NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling Regulated proteolysis of p75NTR NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Lower body strength ( 27325353) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Eosinophil count ( 29403010) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		50 interacting genes: ANXA7 APP BEX1 BEX3 BNIP3L CAV1 CD80 CDKN1A EGR1 FSCN1 GRB2 H2AX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 MDM2 NDN NFKBIB NGF NSMCE3 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TP53 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1 ZNF274	144 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CFTR CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70
Entrez ID		4804	6464
HPRD ID		01197	02780
Ensembl ID		ENSG00000064300	ENSG00000160691
Uniprot IDs		P08138	P29353
PDB IDs		2N80 2N83 2N97 3EWV 5ZGG 7CSQ 8X8T	1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 2L1C 4JMH 4XWX 5CZI 6DM4
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Nerve Growth Factor Signaling Pathway Regulation Of Apoptotic Process Response To Growth Factor Signal Transduction Response To Nerve Growth Factor Regulation Of Protein Metabolic Process Protein-containing Complex Cellular Response To Nerve Growth Factor Stimulus Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Enzyme Binding Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Identical Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Receptor Activity Neurotrophin Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Growth Factor Stimulus Signaling Adaptor Activity Regulation Of Gene Expression Regulation Of Cellular Component Organization Circadian Rhythm Regulation Of Macromolecule Biosynthetic Process Caveolin-mediated Endocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Myelination Apoptotic Signaling Pathway Axon Ensheathment Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Response To Radiation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Receptor Complex Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Plasma Membrane Positive Regulation Of MAPK Cascade Protein Phosphorylation Positive Regulation Of Multicellular Organismal Process Regulation Of Immune System Process Phosphorylation Phosphotyrosine Residue Binding Intracellular Signal Transduction Regulation Of Developmental Process Protein Autophosphorylation Immune System Process Regulation Of Immune Response Regulation Of Programmed Cell Death Regulation Of Cell Adhesion Intracellular Signaling Cassette Response To Growth Factor Cell Activation Cytokine-mediated Signaling Pathway Positive Regulation Of Immune System Process Cell Migration Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Cell Motility
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